Pollen Pollution Strategy of Artemisia and Chenopodiaceae

Abstract

It is known that 30–40% of people in the world population are sensitized to pollen. This phenomenon is exacerbated in contaminated and urbanized areas. Wormwood is one of the main herbaceous allergenic plants, and its pollen is among the ten global aeroallergens. An allergy to it is a common phenomenon on a global scale. The role of pollen the etiology of pollinosis is usually in tandem with wormwood pollen established in Russia, Central Asia and Kazakhstan, Europe and America. The purpose of this article was to develop a pollen strategy for wormwood and pollen as the leading aeroallergen and assessment of their standardized contribution to the aerobiological situation. The SEM images of the studied pollen of wormwood do not show pronounced changes in the structure and sculpture, since it is tolerant to the effects of pollutants. Different types of deformation and modification of sculptural elements were revealed in pollen from the haze family, since their pollen selectively reacts to various pollutants. The strategy for pollen from wormwood and haze pollen is that, due to its strong, prickly exine, and lipophilicity, weed pollen is a very good biological accumulator of all types of gaseous or solid pollutants. In general, this accumulation depends on the physicochemical processes at the surface or cytoplasmic level, independent of the physiological state of pollen. Many biological agents, such as bacteria and fungal spores, can accumulate on the surface layer of the pollen shell and be used for bioindication.

Evaluation of a Novel Adjuvanted Vaccine for Ultrashort Regimen Therapy of Artemisia Pollen-Induced Allergic Bronchial Asthma in a Mouse Model

“…Previously, allergic rhinitis from ragweed pollen was successfully addressed using a commercial product, Pollinex Quattro (Allergy Therapeutics, UK), which contains plant pollen extracts treated with glutaraldehyde, absorbed on L-tyrosine, and adjuvanted with monophosphoryl lipid A (MPL) injected four times 1 week apart ( 23 ), resulting in remission of symptoms for the duration of the allergy season ( 20 ). Wormwood pollen is among the top 10 global aeroallergens that cause allergic rhinitis and bronchial asthma ( 24 ). The goal of this pilot study, therefore, was to similarly test an ultrashort adjuvanted ASIT regimen for wormwood pollen-induced allergic bronchial asthma.…”

A recombinant Artemisia vulgaris pollen adjuvanted Art v 1 protein-based vaccine treats allergic rhinitis and bronchial asthma using pre- and co-seasonal ultrashort immunotherapy regimens in sensitized mice

“…Our previous studies in mice ( 11 ) showed that it is possible to achieve effective therapy of bronchial asthma caused by wormwood pollen ( Artemisia ), one of the ten global aeroallergens ( 12 ), with only four injections (at weekly intervals) of a vaccine based on the recombinant Art v 1 Artemisia vulgaris major protein formulated with ISA-51 adjuvant. However, it is not known whether this vaccine formulation in an ultrashort ASIT regimen can be effective in the treatment of allergic rhinitis, the presence of which has been recognized as an important risk factor for bronchial asthma ( 13 ).…”