Pollen of common ragweed (Ambrosia artemisiifolia L.): Illumina-based de novo sequencing and differential transcript expression upon elevated NO2/O3

Zhao, Feng; Durner, Jörg; Winkler, J. Barbro; Traidl‐Hoffmann, Claudia; Strom, Tim-Matthias; Ernst, Dieter; Frank, Ulrike

doi:10.1016/j.envpol.2017.02.032

Cited by 41 publications

(37 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…reported that traffic‐related pollutants (eg, NO 2 and O 3 ) could trigger the release of allergen‐containing granules from grass pollen and increase the bioavailability of airborne pollen allergens. Another study confirmed that the pollutants NO 2 and O 3 altered levels of allergen‐encoding transcripts of ragweed pollen and corresponding allergenic potential . Consistent with the findings of previous research, the present study showed that grass pollen count was correlated with ozone, SO 2 , and NO x .…”

Section: Discussionsupporting

confidence: 92%

“…This increased bioavailability of airborne pollen allergens has been shown to cause an increased incidence of allergic disease. Several studies have shown that air pollution can affect pollen viability, production, and allergenicity . Hence, there is a need to identify conditions that coincide with high exposure to pollen and air pollution, and to determine the extent to which pollutants contribute to airway symptoms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Associations among air pollutants, grass pollens, and daily number of grass pollen allergen‐positive patients: a longitudinal study from 2012 to 2016

Ouyang

Yin²,

Liu

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background Grass pollen is the most prevalent sensitizing aeroallergen to cause respiratory allergies in northern China. Air pollutants have a substantial effect on respiratory health and some pollens. This study aimed to investigate relationships among airborne grass pollen, air pollutants and allergic diseases, in order to determine their effects on patients with grass pollen allergies in Beijing, China, during the period from 2013 to 2016. Methods Data regarding autumnal grass pollens and air pollutants measured in Beijing from 2012 to 2016 were obtained from local governmental agencies. Patient data regarding specific immunoglobulin E (IgE) analyses from 2013 to 2016 were obtained from the Department of Allergy in Beijing Tongren Hospital. Spearman's rank correlation analysis was used to assess associations between the daily number of grass pollen allergen–positive patients and the following parameters: 3 clinically‐relevant grass pollen genera (Artemisia, Humulus, and Chenopodium) and inhalable pollutants. Results Correlation analysis indicated that the daily number of grass pollen‐positive patients was significantly associated with the peak period of grass pollens, as well as pollutants SO2 and NOx. Moreover, concentrations of air pollutants (eg, ozone, oxides of nitrogen [NOx], and SO2) were consistently and significantly associated with concentrations of grass pollens; particulate matter 2.5 µm in diameter was negatively associated with Artemisia and Chenopodium pollens. Conclusion Grass pollens exhibited substantial impact on allergic disease morbidity. Air pollutants impacted allergic disease and grass pollen. Thus, public health and clinical approaches to anticipate and reduce allergic disease morbidity from pollen and pollutants are needed.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Associations among air pollutants, grass pollens, and daily number of grass pollen allergen‐positive patients: a longitudinal study from 2012 to 2016

Ouyang

Yin²,

Liu

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…A recent study on the highly allergenic common ragweed revealed differentially expressed genes under certain environmental conditions [28]. Here we used RNA-Seq to obtain general gene expression patterns in Betula verrucosa and Pinus sylvestris pollen, before focusing on proteases and protease inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen

Höllbacher

Schmitt

Hofer

et al. 2017

IJMS

View full text Add to dashboard Cite

Pollen is one of the most common causes of allergy worldwide, making the study of their molecular composition crucial for the advancement of allergy research. Despite substantial efforts in this field, it is not yet clear why some plant pollens strongly provoke allergies while others do not. However, proteases and protease inhibitors from allergen sources are known to play an important role in the development of pollen allergies. In this study, we aim to uncover differences in the transcriptional pattern of proteases and protease inhibitors in Betula verrucosa and Pinus sylvestris pollen as models for high and low allergenic potential, respectively. We applied RNA sequencing to Betula verrucosa and Pinus sylvestris pollen. After de-novo assembly we derived general functional profiles of the protein coding transcripts. By utilization of domain based functional annotation we identified potential proteases and protease inhibitors and compared their expression in the two types of pollen. Functional profiles are highly similar between Betula verrucosa and Pinus sylvestris pollen. Both pollen contain proteases and inhibitors from 53 and 7 Pfam families, respectively. Some of the members comprised within those families are implicated in facilitating allergen entry, while others are known allergens themselves. Our work revealed several candidate proteins which, with further investigation, represent exciting new leads in elucidating the process behind allergic sensitization.

show abstract

“…Verantwortlich für deren extreme Allergenität sind die hohe Pollenanzahl und die geringe Pollenkorngröße (15 bis 25 μm) sowie die stark adjuvante Wirkung der Allergene. Trockenstress und Luftschadstoffe [1,2] erhöhen zusätzlich Allergenität und Ausbreitung. Ambrosia wird zukünftig in immer mehr Regionen Europas gedeihen [3,] die Sensibilisierungsrate sehr wahrscheinlich stark ansteigen.…”

Section: Transfer In Die Praxis Von Prof Dr Claudia Traidl-hoffmannunclassified

Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa

Traidl‐Hoffmann

2019

Kompass Pneumol

Self Cite

View full text Add to dashboard Cite

Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen. Therefore ragweed is becoming domestic in non-invaded areas which in turn will increase the sensitization rate. So far 11 ragweed allergens have been described and, according to IgE reactivity, Amb a 1 and Amb a 11 seem to be major allergens. Sensitization rates of the other allergens vary between 10 and 50%. Most of the allergens have already been recombinantly produced, but most of them have not been characterized regarding their allergenic activity, therefore no conclusion on the clinical relevance of all the allergens can be made, which is important and necessary for an accurate diagnosis. Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen extract or Amb a 1 only. In order to improve ragweed pollen AIT, new strategies are required with higher efficacy and safety.

show abstract

Pollen of common ragweed (Ambrosia artemisiifolia L.): Illumina-based de novo sequencing and differential transcript expression upon elevated NO2/O3

Cited by 41 publications

References 100 publications

Associations among air pollutants, grass pollens, and daily number of grass pollen allergen‐positive patients: a longitudinal study from 2012 to 2016

Associations among air pollutants, grass pollens, and daily number of grass pollen allergen‐positive patients: a longitudinal study from 2012 to 2016

Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen

Pollenallergie gegen Ambrosia: Belastungen, Merkmale und Umgang mit einem importierten Allergieverursacher in Europa

Contact Info

Product

Resources

About