Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey

Kim, Mi Ae; Kim, Dong Kyu; Yang, Hyeon Jong; Yoo, Young; Ahn, Young Min; Park, Hae‐Sim; Lee, Hyun Jong; Jeong, Yi Yeong; Kim, Bong Seong; Bae, Woo Yong; Park, Yang; Koh, Young Il; Lee, Jaechun; Lim, Dae Hyun; Kim, Jeong Hee; Lee, Sang Min; Kim, Yong Min; Jun, Young Joon; Kim, Hyo Yeol; Kim, Yunsun; Choi, Jeong Hee

doi:10.4168/aair.2018.10.6.648

Cited by 42 publications

(62 citation statements)

References 23 publications

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“…14) In a recent nationallevel multicenter study in South Korea, the prevalence of PFAS was 42.7% in pediatric patients with pollen allergy. 11) A recent the doctors estimated a much lower prevalence than what was actually published. The authors argued that it reflects a low index of suspicion and underdiagnosis of PFAS.…”

Section: Epidemiologymentioning

confidence: 93%

“…10) A recent Korean multicenter study reported that the prevalence of PFAS was 41.7% in patients with pollen allergy, 20%-30% in cases of sensitization to summer or autumn pollen alone, and higher than 50% in simultaneous sensitization to spring and autumn pollen or sensitization to all spring, summer, and autumn pollens. 11) Data on the prevalence of PFAS in children are limited. The prevalence of PFAS has been reported differently depending on the country, target group, and reporter.…”

Section: Epidemiologymentioning

confidence: 99%

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Pollen-food allergy syndrome in children

Jeon

2020

Clin Exp Pediatr

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Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods-such as fruits, vegetables, or nuts-in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. PFAS is often called oral allergy syndrome because of mild symptoms such as itching, urticaria, and edema mainly in the lips, mouth, and pharynx that appear after food ingestion. However, reports of systemic reactions such as anaphylaxis have been increasing recently. This diversity in the degree of symptoms is related to the types of trigger foods and the characteristics of allergens, such as heat stability. When pediatric patients with pollen allergy are treated, attention should be paid to PFAS and an active effort should be made to diagnose it.

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Section: Epidemiologymentioning

confidence: 93%

Section: Epidemiologymentioning

confidence: 99%

Pollen-food allergy syndrome in children

Jeon

2020

Clin Exp Pediatr

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“…Reactions of class 2 (≥ 0.70 IU/mL) or higher were considered positive 1819. Singleplex allergen-sIgE levels were measured using ImmunoCAP (Thermo Fisher Scientific/Phadia, Uppsala, Sweden); levels >0.35 kU/L were regarded as positive 1320. All tests were carried out according to the standard instructions.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, several studies revealed the epidemiology of adult FA in Korea 11121314. However, as the study sample was relatively small, their findings may not represent nationwide trends; moreover, patients differed by institution and region.…”

Section: Introductionmentioning

confidence: 93%

Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study

Lee

Kim

Park

et al. 2019

Allergy Asthma Immunol Res

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Purpose To investigate the causative allergens and clinical characteristics of Korean adult patients with food allergy (FA). Methods This retrospective, cross-sectional single-institutional study enrolled Korean adult patients (n = 812) suspected of having FA. For diagnosis, causality assessment history taking, ImmunoCAP specific immunoglobulin E measurement and/or skin prick test were performed. Results Among 812 patients, 415 were diagnosed as having FA. The most common causative allergen was fruit, with a diagnosis of pollen food allergy syndrome (PFAS: 155, 37.3%), followed by crustaceans (111, 26.7%), wheat (63, 15.1%), fruits in patients without PFAS(43, 10.3%), buckwheat (31, 7.4%), peanut (31, 7.4%), walnut (25, 6.0%), red meat due to reaction to galactose-α-1,3-galactose (α-Gal) (8, 1.9%), and silkworm pupa (13, 3.1%). Allergy to egg, milk, fish, or shellfish was rare in Korean adults. One-third of patients with FA exhibited multiple FAs (238/415, 57.3%); the average number of causative allergens was 2.39. About 129 patients (31.0%) were diagnosed as having anaphylaxis; in these patients, wheat was the most frequent causative food. Twenty patients were further diagnosed with food-dependent exercise-induced anaphylaxis (FDEIA); all were due to wheat. In particular, crustaceans, wheat, PFAS, buckwheat, and red meat (α-Gal) were also frequent causes of anaphylaxis. Conclusions Wheat, fruits with or without PFAS, and crustaceans are important and frequent causative allergens in Korean adult FA; these allergens differ from those found in childhood FA. It is notable that non-classic allergies, such as PFAS, FDEIA, and α-Gal allergy, are the important causes of anaphylaxis in Korean adult FA.

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“…In Europe, 70% of birch pollen allergy patients have accompanying varying degrees of food allergy [ 1 ]. Their symptoms are mainly shown after ingesting birch pollen-related foods [ 2 ], at least in part because of the cross-reaction between Bet v 1 homologous protein in food and the major allergen Bet v 1 in birch pollen, including apple (Mal d 1), cherry (Pru av. 1), pear (Pyr c 1), hazelnut (Cor a 1), celery (Api g 1), carrot (Dau c 1), soybean (Gly m 4), peanut (Ara h 8), jackfruit, and kiwi (Act d 8) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Chinese Birch Pollen Allergy and Immunotherapy in Mice

Xie

Yin

2019

Inflammation

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Birch pollen allergy is a common cause of spring pollinosis in China. However, there is little research on birch pollen allergen in China and only the major allergen (Bet v 1) has been fully characterized. Chinese birch pollen-induced airway inflammation models in BALB/c mice were developed and administered subcutaneous immunotherapy (SCIT). BALB/c mice were sensitized subcutaneously on days 1, 8, and 15 with 25 μg/μL birch pollen extract. On days 24–26, the mice were challenged with 0.1% birch pollen aerosol. To investigate the efficacy of SCIT, mice were subcutaneously injected 0.3 mg birch pollen extract (BPE) with or without being adsorbed to alum. Airway hyper-responsiveness (AHR) to methacholine and immunological parameters was detected. Western blot analysis was applied with mice serum and mass spectrometry was used to identify the IgE-binding bands in birch pollen. Compared with PBS group, birch pollen sensitization and challenge BALB/c mice developed AHR, and IL4, IL5, IL6, IL10, and IL17 were significantly higher. Mice sensitized by birch pollen showed increased plasma levels of anti-BPE IgE, IgG1, and IgG2a. Histologic analyses showed that mice had peribranchial infiltration of inflammatory cells and mucosal hyperplasia. After SCIT, allergic symptoms effectively alleviated and kept for a long time. Interestingly, mice serum pool showed strong reactions to 70-kDa proteins. Mass spectrometry data suggests that the 70-kDa protein belongs to the HSP 70 family. SCIT inhibited the inflammatory response in the long term and a 70-kDa protein potentially belonging to the HSP 70 family plays a significant role in Chinese birch pollen-induced mice model.

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Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey

Cited by 42 publications

References 23 publications

Pollen-food allergy syndrome in children

Pollen-food allergy syndrome in children

Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study

Chinese Birch Pollen Allergy and Immunotherapy in Mice

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