Pollen‐derived low‐molecular weight factors inhibit 6‐sulfo LacNAc⁺ dendritic cells' capacity to induce T‐helper type 1 responses

Abstract

Our data show that slanDCs, a subset of human blood DCs with constitutively high potency to induce Th1 responses, are susceptible to the Th2 polarizing effect of low molecular weight, non-protein factors derived from pollen.

Pollen metabolome analysis reveals adenosine as a major regulator of dendritic cell–primed TH cell responses

“…10 For details on donor characterization, see the Methods section of this article's Online Repository at www.jacionline.org.…”

“…9 Second, APEs, but not E 1 phytoprostanes, inhibit the LPS-induced upregulation of maturation markers in peripheral blood-derived 6-sulfo LacNAc 1 (slan) DCs. 10 Third, in an animal sensitization model to the allergen ovalbumin, animals exposed to intranasal APE/ovalbumin exhibit reduced T H 1 and enhanced T H 2 responses in draining lymph node CD4 1 T cells, whereas exposure to ovalbumin/E 1 phytoprostanes leads to a downregulation of both T H 1 and T H 2 responses. 11 Finally, APEs, but not PPE 1 , induced Ca 21 transients and DC chemotaxis (unpublished data).…”

Do lipids influence the allergic sensitization process?

“…PALMs were identified in aqueous extracts from tree, weed, and grass pollen 56 . 6-Sulfo LacNac + DCs, the most abundant native DC population in human peripheral blood with a constitutively high potency to induce T H 1 responses, were shown to be susceptible to the T H 2-polarizing effect of PPE 1 from birch pollen 40 . PPE 1 inhibited the LPS-induced IL-12 p70 production and the secretion of IL-6.…”

Die Achse Umwelt‐Erreger‐Wirt bei übertragbaren und nicht übertragbaren Krankheiten: Jüngste Fortschritte in der experimentellen und klinischen Forschung

“…An ihrem Beispiel lässt sich zeigen, wie Pollenkörner dem angeborenen Immunsystems irreleitende Gefahrsignale aussenden. Andere PALMs, die eine strukturelle Ähnlichkeit mit den Prostaglandinen aus Säugetierzellen aufweisen, modulieren dendritische Zellen, so dass diese eine Th2-gewichtete T-Zell Antwort induzieren und die Differenzierung naiver T-Zellen zu Th-1-Zellen hemmen [11][12][13]. Darüber hinaus produzieren dendritische Zellen unter dem Einfluss der PALMs Chemokine, die vermehrt Th2-Zellen rekrutieren [14].…”