Polished Nanopipets: New Probes for High-Resolution Scanning Electrochemical Microscopy

Elsamadisi, Pansy; Wang, Yixian; Velmurugan, Jeyavel; Mirkin, Michael V.

doi:10.1021/ac102704z

Cited by 39 publications

(38 citation statements)

References 24 publications

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“…A pipette with a radius as small as~8 nm has previously been used in an SECM experiment, and the minimum attainable separation distance was < 1 nm. [20] Similar positioning capabilities can be expected for SICM.…”

mentioning

confidence: 58%

Delivery of Single Nanoparticles from Nanopipettes under Resistive‐Pulse Control

2014

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mentioning

confidence: 58%

Delivery of Single Nanoparticles from Nanopipettes under Resistive‐Pulse Control

2014

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“…The intrinsic size and roughness of quartz nanopipet tips were observable by TEM with higher resolution in this study than by SEM in previous studies, 3,14,16,17 not only because TEM does not need the metal coating of a nanopipet, but also because we optimized the intensity of the electron beam for TEM not to melt or deform the insulating nanotip at high magnification. 18,19,29,34 Moreover, a periodic array of 100 nm-diameter nanopores was imaged in this study in contrast to our previous study of randomly distributed nanopores with various sizes and shapes.…”

Section: Discussionmentioning

confidence: 67%

“…The roughness of a borosilicate nanopipet tip was imaged previously by SEM, which required a metal-coated nanopipet with a larger diameter of ~150 nm. 17 …”

Section: Resultsmentioning

confidence: 99%

Characterization of Nanopipet-Supported ITIES Tips for Scanning Electrochemical Microscopy of Single Solid-State Nanopores

et al. 2017

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Nanoscale scanning electrochemical microscopy (SECM) is a powerful scanning probe technique that enables high-resolution imaging of chemical processes at single nanometer-sized objects. However, it has been a challenging task to quantitatively understand nanoscale SECM images, which requires to accurately characterize the size and geometry of nanoelectrode tips. Herein, we address this challenge through transmission electron microscopy (TEM) of quartz nanopipets for SECM imaging of single solid-state nanopores by using nanopipet-supported interfaces between two immiscible electrolyte solutions (ITIES) as tips. We take advantage of the high resolution of TEM to demonstrate that laser-pulled quartz nanopipets reproducibly yield not only an extremely small tip diameter of ~30 nm, but also a substantial tip roughness of ~5 nm. The size and roughness of a nanopipet can be reliably determined by optimizing the intensity of the electron beam not to melt or deform the quartz nanotip without metal coating. Electrochemically, the nanoscale ITIES supported by a rough nanotip gives higher amperometric responses to tetrabutylammonium than expected for a 30 nm-diameter disk tip. The finite element simulation of sphere-cap ITIES tips accounts for the high current responses and also reveals that the SECM images of 100 nm-diameter Si3N4 nanopores are enlarged along the direction of the tip scan. Nevertheless, spatial resolution is not significantly compromised by a sphere-cap tip, which can be scanned in closer proximity to the substrate. This finding augments the utility of a protruded tip, which can be fabricated and miniaturized more readily to facilitate nanoscale SECM imaging.

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“…The nanopipet-supported ITIES was used as an SECM tip to confirm that the nanoscale interface is flush with the surrounding surface of the pipet tip [35, 37]. A sharp nanopipet with a small RG value of ~1.5 (Figure 2B) can approach very close to a target substrate for obtaining highly quantitative kinetic data and high-resolution images.…”

Section: Electrochemical Measurement Of It At the Nanopipet-suppormentioning

confidence: 99%

Electrochemical sensing and imaging based on ion transfer at liquid/liquid interfaces

Amemiya

Kim

Izadyar

et al. 2013

Electrochimica Acta

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Here we review the recent applications of ion transfer (IT) at the interface between two immiscible electrolyte solutions (ITIES) for electrochemical sensing and imaging. In particular, we focus on the development and recent applications of the nanopipet-supported ITIES and double-polymer-modified electrode, which enable the dynamic electrochemical measurements of IT at nanoscopic and macroscopic ITIES, respectively. High-quality IT voltammograms are obtainable using either technique to quantitatively assess the kinetics and dynamic mechanism of IT at the ITIES. Nanopipet-supported ITIES serves as an amperometric tip for scanning electrochemical microscopy to allow for unprecedentedly high-resolution electrochemical imaging. Voltammetric ion sensing at double-polymer-modified electrodes offers high sensitivity and unique multiple-ion selectivity. The promising future applications of these dynamic approaches for bioanalysis and electrochemical imaging are also discussed.

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Polished Nanopipets: New Probes for High-Resolution Scanning Electrochemical Microscopy

Cited by 39 publications

References 24 publications

Delivery of Single Nanoparticles from Nanopipettes under Resistive‐Pulse Control

Delivery of Single Nanoparticles from Nanopipettes under Resistive‐Pulse Control

Characterization of Nanopipet-Supported ITIES Tips for Scanning Electrochemical Microscopy of Single Solid-State Nanopores

Electrochemical sensing and imaging based on ion transfer at liquid/liquid interfaces

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