Pólipos serrados y su asociación con neoplasia avanzada de colon

Urmán, Jesús; Gómez, Marta; Basterra, Marta; Mercado, María del Rosario; Montes, Marta; Dorronsoro, Marisa Gómez; Garaigorta, Maitane; Fraile, María; Rubio, Eva; Aisa, Gregorio; Galbete, Arkaitz

doi:10.1016/j.gastrohep.2015.12.010

Cited by 4 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is considerable evidence to suggest that the immune system plays a protective role in tumorigenesis (22–24). Correlation between serrated polyps and colorectal neoplasia has been largely reported (25–27). Approximately 15–20% of all sporadic CRCs arise via the serrated pathway, in which serrated polyps may be the precursor lesions (28, 29).…”

Section: Introductionmentioning

confidence: 99%

Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps

et al. 2017

View full text Add to dashboard Cite

Regulatory T cells (Tregs), a subset of CD4+ or CD8+ T cells, play a pivotal role in regulating immune homeostasis. An increase in Tregs was reported in many tumors to be associated with immune suppression and evasion in cancer patients. Despite the importance of Tregs, the molecular signatures that contributed to their pathophysiological relevance remain poorly understood and controversial. In this study, we explored the gene expression profiles in Tregs derived from patients with colorectal cancer [colorectal carcinoma (CRC), n = 15], colorectal polyps (P, n = 15), and in healthy volunteers (N, n = 15). Tregs were analyzed using CD4+CD25+CD127lowFoxP3+ antibody markers. Gene expression profiling analysis leads to the identification of 61 and 66 immune-related genes in Tregs derived from CRC and P patients, respectively, but not in N-derived Treg samples. Of these, 30 genes were differentially expressed both in CRC- and P-derived Tregs when compared to N-derived Tregs. Most of the identified genes were involved in cytokine/chemokine mediators of inflammation, chemokine receptor, lymphocyte activation, and T cell receptor (TCR) signaling pathways. This study highlights some of the molecular signatures that may affect Tregs’ expansion and possible suppression of function in cancer development. Our findings may provide a better understanding of the immunomodulatory nature of Tregs and could, therefore, open up new avenues in immunotherapy.

show abstract