Poliovirus serotype 2 and coxsackievirus A promote the natural recombination of poliovirus

Qian, Yongjiang; Pu, Xufeng; Yu, Yu; Yu, Xintian; Kong, Liang; Liu, Lu; Wang, Hua; Shen, Han‐Xi

doi:10.1002/jmv.25620

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…There is evidence that EV-Cs can recombine with PVs or VDPVs, resulting in changes in virulence and transmission. [33][34][35] As a recently discovered EV, EV-C96 has been isolated from many countries and regions; however, its biological characteristics and pathogenicity are still unclear. Therefore, research focused on EV-Cs is needed.…”

Section: Reports Of Ev-cs Have Recently Increasedmentioning

confidence: 99%

Characterizing enterovirus C96 genome and phylodynamics analysis

Yang,

Sun,

Yan

et al. 2023

Journal of Medical Virology

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Enterovirus C96 (EV‐C96) is a recently discovered serotype belonging to enterovirus C species. It had been isolated from patients with acute flaccid paralysis, hand, foot, and mouth disease, diarrhea, healthy people, or environmental specimens. Despite increasing reports of the virus, the small number of full‐length genomes available for EV‐C96 has limited molecular epidemiological studies. In this study, newly collected rare EV‐C96 strains in China from 1997 to 2020 were combined with sequences available in GenBank for comprehensive analyses. Sequence analysis revealed that the nucleotide sequence similarity of EV‐C96 and the prototype strain (BAN00‐10488) was 75%–81.8% and the amino acid sequence similarity was 85%–94.9%. EV‐C96 had a high degree of genetic variation and could be divided into 15 genogroups. The mean evolutionary rate was 5.16 × 10−3 substitution/site/year, and the most recent common ancestor was dated to 1925. A recombination analysis revealed that EV‐C96 may be a recombinant derived from other serotypes in the EV‐C group in the nonstructural protein coding region. This comprehensive and integrated analysis of the whole genome sequence of EV‐C96 provides valuable data for further studies on the molecular epidemiology of EV‐C96 worldwide.

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Section: Reports Of Ev-cs Have Recently Increasedmentioning

confidence: 99%

Characterizing enterovirus C96 genome and phylodynamics analysis

Yang,

Sun,

Yan

et al. 2023

Journal of Medical Virology

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“…Recombination occurs between divergent positive-sense RNA viruses [9,15,16], and is a common phenomenon [7,9,11,[14][15][16]. However, the recombination of HEV has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

A quadruple recombination event discovered in hepatitis E virus

et al. 2021

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Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but the recombination of HEV has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 557 complete HEV genomes in GenBank. A potentially signi cant quadruple recombination event was identi ed by recombination detection analysis. The recombinant progeny virus HEV_32_Manchester_301214 was produced by recombination between the major parent HEPAC-44 and the minor parent HE-JA15-1335, thereby re ecting inter-genotype recombination.HEV_32_Manchester_301214 and HEPAC-44 belong to genotype 3, while HE-JA15-1335 belongs to genotype 1, and these three strains have all been separated from humans. Three breakpoints of the four recombination events occurred in the ORF2 region, while another occurred in the ORF1 region. This quadruple recombination event was con rmed by phylogenetic analysis. The genotype, host and the recombination regions of the three strains were analyzed. These results of the analyses provide valuable suggestions for future research on HEV diversity.

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Quadruple Recombination Events Discovered in Hepatitis E Virus

Shen

Liu

Ding

et al. 2021

Preprint

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Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but the recombination of HEV has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 557 complete HEV genomes in GenBank. A potentially significant quadruple recombination event was identified by recombination detection analysis. The recombinant progeny virus HEV_32_Manchester_301214 was produced by recombination between the major parent HEPAC-44 and the minor parent HE-JA15-1335, thereby reflecting inter-genotype recombination. HEV_32_Manchester_301214 and HEPAC-44 belong to genotype 3, while HE-JA15-1335 belongs to genotype 1, and these three strains have all been separated from humans. Three breakpoints of the four recombination events occurred in the ORF2 region, while another occurred in the ORF1 region. This quadruple recombination event was confirmed by phylogenetic analysis. The genotype, host and the recombination regions of the three strains were analyzed. These results of the analyses provide valuable suggestions for future research on HEV diversity.

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Poliovirus serotype 2 and coxsackievirus A promote the natural recombination of poliovirus

Cited by 3 publications

References 33 publications

Characterizing enterovirus C96 genome and phylodynamics analysis

Characterizing enterovirus C96 genome and phylodynamics analysis

A quadruple recombination event discovered in hepatitis E virus

Quadruple Recombination Events Discovered in Hepatitis E Virus

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