Poliovirus antibody in urban school children

Linnemann, Calvin C.; Stefanovic, Gerda M.; Shea, Linda; May, Don B.; Schiff, Gilbert M.

doi:10.1016/s0022-3476(74)80725-0

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…The geometric mean titer for all three polio types fell to this level when the last TOPV admin¬ istration had been five to six years or more previously. 4. Antibody response to booster vaccination was of the IgG type, indi¬ cating previous sensitization and not primary vaccine failure, but more likely a loss of antibody to the point where reinfection with vaccine virus did occur.…”

Section: Resultsmentioning

confidence: 97%

Oral Polio Vaccine

Bass¹

1978

JAMA

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We studied the persistence of antibody after vaccination and the response to booster revaccination with trivalent oral polio vaccine (TOPV) administered at varied intervals after the primary series in a large group of children. Decline in antibody was related to intervals since last vaccination, and not to sex, age, age at primary vaccination, or type and number of previous administrations. Geometric mean titers of neutralizing antibody were 11.3 for type 1 and 8.0 for types 2 and 3 poliovirus when vaccine had been given within the previous year, declining to 3.2, 3.0, and 2.1 for types 1, 2, and 3 after nine years. Most children with an initial titer of 4 or less responded to revaccination with a fourfold or greater increase in titer of IgG. Geometric mean titers for all three types of polio dropped to this level when last TOPV administration had been five to six years or more.

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Section: Resultsmentioning

confidence: 97%

Oral Polio Vaccine

Bass¹

1978

JAMA

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Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series

Bass

Halstead

Fischer

et al. 1978

JAMA: The Journal of the American Medical Association

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Antipoliomyelitis immunity status among a population that was regularly vaccinated 11?12 years before

Bellelli

Tanzi

Bocelli³

et al. 1991

Eur J Epidemiol

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A study of poliomyelitis neutralizing antibodies was carried out on 165 samples of blood serum drawn from subjects aged 14-15 years who had completed vaccination with OPV 11 or 12 years ago. Two different methods of incubation of the serum-virus mixtures (1 hour at 37 degrees C; 6 hours at 37 degrees C and then 18 hours at 4 degrees C, respectively) and two different cell lines (RC-37 and Hep-2) for the inoculation of these mixtures were employed. The results were also evaluated in relation to different initial dilutions of the sera (from 1:4 to 1:1). With the 1:4 initial serum dilution the highest frequencies of sero-negativity were observed utilizing the short incubation time and inoculation in Hep-2 (42% for polio 1, 10% for polio 2, 32% for polio 3). These frequencies diminish significantly utilizing the RC-37 cell line and the long incubation respectively. Under all the experimental conditions the results were better when the 1:2 initial serum dilutions were employed and even better when undiluted sera were used. Neutralizing antibodies against the 3 types of poliovirus were detected in the undiluted sera of all the subjects utilizing the long incubation and inoculation in either the RC-37 or the Hep-2 cell lines. In three subjects lacking detectable antibodies at the 1:4 dilution of the sera, the administration of a dose of IPV produced after 5-7 days a high response which remained almost unchanged 30 days later.

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Poliovirus antibody in urban school children

Cited by 7 publications

References 5 publications

Oral Polio Vaccine

Oral Polio Vaccine

Oral polio vaccine. Effect of booster vaccination one to 14 years after primary series

Antipoliomyelitis immunity status among a population that was regularly vaccinated 11?12 years before

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