Poliomyelitic Virus from Feces in Non-Paralytic Poliomyelitis. II. Infectivity by Various Routes.

The Susceptibility of Infant Rhesus Monkeys to Poliomyelitis Virus Administered by Mouth

“…This difficulty was anticipated by Burnet and his colleagues who blocked the nasal pathway in some of their animals by preliminary application of a ZnS04 spray to the nasal mucosa.) Subsecluenfly, cynomolgus monkeys have been infected a number of times by oral administration of virus (1, 23,24) and other species a few times: M. irus (mordax) 1 in one of eleven trials (23,26) the green African monkey, Cerco~thecus adhiops s~eus, in one of seventeen (25,26). Negative results have been obtained with one capuchin (Cebus faIa~ellus) (25), one grivet (Cercop//hecus griseo~iridis), (28), seven vervets, Cerco~ithecus a#ghiops #ygeryJhrus, (27,28), two M. sinicus (29,30), and two baboons one of which was of the species Pa#io hacn~ryas (27,31).…”

“…Leiner and von Wiesner (11) reported a single positive, although it is not entirely certain that the species used was M. mu/a~. In recent unpublished experiments from our laboratory, one young rhesus of eight fed the Y-SK strain developed paralytic poliomyelitis (32); previous experience with feeding this strain of virus to young adult rhesus monkeys had been negative (23).…”

Experimental Poliomyelitis in Cercopithecus Aethiops Sabaeus (The Green African Monkey) by Oral and Other Routes

“…experimental poliomyelitis can be produced by feeding (7,8). This has been confirmed by Saddington (9), Vignec et al (10), and Burnet et al (4). Infection by feeding has not been described in M. rhesus.…”

“…The olfactory bulbs were not examined. In an earlier generation, the SK strain of virus had led to infection after feeding in M. cynomolgus and M. mordax, but not in M. mulatta (10).…”

Transmission of Virus Diseases by Water

“…The usual human portal of entry of poliomyelitis virus cannot as yet be said to be clearly established. There is, however, an accumulated weight of evidence which points toward the gastro-intestinal tract as the probable portal (6)(7)(8)(9)(10)(11). An increasing number of investigators are leaning toward the belief that although poliomyelitis is essentially a disease affecting the central nervous system, it may be a "digestive tract disease" in that the virus may enter the body through one end of the tract and leave by way of the opposite end.…”