Polineuropatia periférica induzida por benzonidazol no tratamento da doença de Chagas

Abstract

Neurophysiological examination before and after the administration of benzonidazole, has shown peripheral polyneuropathy induced by this drug in most of the patients treated for chronic Chagas' disease. The polyneuropathy was mostly axonal and it was dose dependent being more severe in patients who had denervation of skeletal muscles before receiving the drug.

Involvement of the central nervous system in the chronic form of Chagas' disease

“…Thus the absence of knee and ankle jerks in 9 of our patients may be attributed to a peripheral neuropathy (PN). Our patients did not use drugs against T. cruzi, which could have provoked a PN [41].…”

Pediatric Clinical Pharmacology Studies in Chagas Disease

“…The study [60] was designed as an observational, prospective, polyneuropathy, in particular, is a frequent observation in the adult population pharmacokinetics study, enrolling children with Chapopulation (about 20% of treated patients), but is rare in chil-gas disease of both sexes who were 2-12 years of age and eligible dren. [29,46,47] Its incidence and severity in adults are dose-depen-for treatment with benznidazole, as per current treatment protodent; this has been confirmed in experiments in dogs. [47,48] cols.…”