Polifarmacia y síndrome serotoninérgico

Aspas, R Dolz; Rodrigo, M C Juyol; Sánchez, P.

doi:10.4321/s0212-71992008000700015

Cited by 2 publications

(1 citation statement)

References 6 publications

(21 reference statements)

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“…60 Positron emission tomography (PET) scan studies in two healthy men show a blockade of 85% and 95% of 5-HT2 receptors in the prefrontal cortex, respectively, with 12 mg and 18 mg daily over 6 days. 61 In SS, an initial dose of 12 mg is recommended, followed by 2 mg every 2 h to a maximum of 32 mg in 24 h until symptoms settle. 62 This dose was insufficient in our case.…”

Section: Understanding Hypertension In the Context Of Serotonin Toxicitymentioning

confidence: 99%

Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques

Ott

Mannchen

Jamshidi

et al. 2019

Therapeutic Advances in Psychopharmacology

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Serotonin syndrome is thought to arise from serotonin excess. In many cases, symptoms are mild and self-limiting. But serotonin syndrome can become life threatening, when neuromuscular hyperexcitability spins out of control. Uncontainable neuromuscular hyperexcitability may lead to cardiovascular complications, linked to extreme changes in blood pressure. Currently, there is little guidance on how to control blood pressure in hyperserotonergic states. We report a case with treatment-resistant arterial hypertension, followed by a clinical review (using systematic review principles and techniques) of the available evidence from case reports published between 2004 and 2016 to identify measures to control arterial hypertension associated with serotonin syndrome. We conclude that classic antihypertensives may not be effective for the treatment of severe hypertension associated with serotonin syndrome. Benzodiazepines may lower blood pressure. Patients with severe hypertension not responding to benzodiazepines may benefit from cyproheptadine, propofol or both. In severe cases, higher cyproheptadine doses than currently recommended may be necessary.

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Section: Understanding Hypertension In the Context Of Serotonin Toxicitymentioning

confidence: 99%