This chapter introduces the contested problem of how badgers and bovine TB are connected—and what to do about it—outlining the key events explored across the rest of the volume. I will discuss how my analytical approach to this research falls into three key themes: knowledge controversies and epistemic communities; good care, good work, good knowledge; and animal roles and traces. I then explore two historical backstories essential for understanding this controversy: the history of tuberculosis itself (in humans and other animals); and the history of the Great British Badger Debate, which stretches back to the Victorian era and beyond. Finally, this chapter will provide an overview of the rest of the book, summarising the overall structure and content of the chapters to come.