Polarographic study of uracil derivatives

Bouzid, B.; Macdonald, A.M.G.

doi:10.1016/s0003-2670(00)83677-6

Cited by 18 publications

(10 citation statements)

References 21 publications

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“…It has been observed that the cathodic stripping response can be obtained within the pH region 6-8. The voltammetric response is best shaped in neutral medium, which is in agreement with the findings of other investigators [6,9]. In acidic medium the CSSWV response was not observed.…”

Section: Resultssupporting

confidence: 92%

“…Using differential pulse cathodic stripping voltammetry, a linear calibration plot was established within the concentration range from 0.5 to 5× 10 − 7 mol l − 1 . Bouzid and Macdonald found that the cathodic stripping response of FU is markedly sensitive to the presence of Cu(II) ions [6]. Recently, Khodari at al.…”

Section: Introductionmentioning

confidence: 99%

“…Wrona and Czochralska [5] reported a four electron reduction process of FU at rather negative potentials. Utilizing the capability of FU to create slightly soluble mercury salts, several cathodic stripping methods for its quantitative determination have been developed [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…A detailed study of 18 uracil derivatives, including FU, by dc polarography, differential pulse polarography, and differential pulse cathodic stripping voltammetry has been performed by Bouzid and Macdonald [6]. These authors concluded that two electrons are involved in the redox reaction of mercury in the pres-ence of FU due to formation of sparingly soluble complexes.…”

Section: Introductionmentioning

confidence: 99%

“…In analytical methods for determination of FU reported so far [6][7][8][9], it is pointed out that the sensitivity of a particular method can be significantly enhanced in the presence of Cu(II) ions. The theoretical results presented in this paper provide a base for understanding the influence of Cu(II) on the voltammetric response of FU.…”

Section: Introductionmentioning

confidence: 99%

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Square-wave voltammetry of 5-fluorouracil

Mirčeski

Gulaboski

Jordanoski

et al. 2000

Journal of Electroanalytical Chemistry

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The redox reaction of 5-fluorouracil (FU) at a hanging mercury drop electrode (HMDE) is studied by means of square-wave voltammetry (SWV). It is demonstrated that the redox reaction proceeds according to the scheme:− , which involves both chemisorption of FU on the electrode surface and creation of a sparingly soluble compound with the electrode material. The overall response exhibits properties of a surface process in which both the reactant and the product of the redox reaction are immobilized on the electrode surface. The square-wave voltammetric response of FU possesses features typical of surface confined processes such as 'split SW peaks' and a 'quasi-reversible maximum'. The proposed electrode mechanism is studied theoretically. The numerically calculated response under conditions of SWV is in qualitative agreement with the experimental data. Comparing the theoretical and the experimental data, the kinetic parameters of the redox reaction investigated are estimated. The standard rate constant appears to be within the interval 545 k s /s − 1 5 108, the adsorption constant is K =10 cm − 1 , and the transfer coefficient is h =0.549 0.01. The effect of the Cu(II) ions on the adsorptive SWV response of FU is discussed from an analytical point of view. It is demonstrated that SWV is a particularly appealing technique, which enables determination of FU at an ultra-trace concentration level. A linear calibration plot was established at 10 − 11 mol l − 1 concentration level with a correlation coefficient of R 2 = 0.992. The detection limit is 7.7× 10 − 12 mol l − 1 . The reproducibility of the results in terms of the relative standard deviation ranges from 0.9 to 3.2%.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Square-wave voltammetry of 5-fluorouracil

Mirčeski

Gulaboski

Jordanoski

et al. 2000

Journal of Electroanalytical Chemistry

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Square-Wave Voltammetry of a Second Order Cathodic Stripping Process Coupled by Adsorption of the Reacting Ligand

2002

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Electrochemical Analysis of Nucleic Acids

Paleček

Fojta

Jelen

et al. 2002

Encyclopedia of Electrochemistry

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The sections in this article are Introduction History Nucleic Acid Samples Electrochemical Behavior of NA Components Adsorption/Desorption Behavior Mercury Electrodes Solid Electrodes Reduction and Oxidation Microanalysis of Nucleic Acid Components by Stripping Techniques Principles Reactions of Pyrimidine and Purine Bases with the Electrode Mercury Unusual Bases and Nucleosides Sparingly Soluble Compounds of Nucleic Acid Components with Copper Adsorption/Desorption Behavior of NAs Mercury Dropping Electrode Adsorption of Double‐stranded (Native) DNA Adsorption of Single‐stranded (Denatured) DNA Adsorption Kinetics at Mercury Dropping and Hanging Electrodes Electrochemical Impedance Spectroscopy ( EIS ) Other Techniques Adsorption of NAs on Other Electrodes DNA Adsorption to Charged Lipid Membranes Reduction and Oxidation of NAs on Different Electrodes Mercury Electrodes Reduction of Adenine and Cytosine Residues Anodic Signal of Guanine Residues Carbon Electrodes Other Solid Electrodes Analysis of NAs by Different Electrochemical Techniques Relations Between Structures and Electrochemical Responses of DNA DNA Structure on Electrode Surfaces Dependence of the ds DNA Signals at the HMDE on Potential Scanning Direction Opening of the DNA Double Helix Around −1.2 V (Region U ) Opening of ds DNA at Acid p Hs in a Wider Potential Range T Interactions of NAs with Small Molecules Reversible (Noncovalent) Interactions Inorganic Cations and Simple Metal Complexes Organic Metal Chelates Other Noncovalent DNA Binders Covalent Interactions Electroactive Markers of NAs Other Nucleic Acid Modifications DNA Conductivity Application of Electrodes in DNA Conductivity Studies Analytical Applications Sensors for DNA Hybridization Immobilization of DNA on the Electrode Detection of the Hybridization Event Redox Indicators Covalently Bound to DNA Indicator‐free Detection Systems. Intrinsic Electroactivity of DNA Changes in Interfacial Properties and DNA Conductivity Blocking and Interfacing the Transducer Electrocatalytic Reactions Detection of Point Mutations Sensors for DNA Damage Detection of DNA Strand Breaks Damage to DNA Bases Detection of Damaging Agents Specifically Interacting with DNA DNA Cleavage Controlled by Electrochemical Reactions Other Determinations Determination of ss DNA in an Excess of ds DNA Determination of RNA Traces in DNA Solutions Determination of Proteins Conclusion Addendum Acknowledgment

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Polarographic study of uracil derivatives

Cited by 18 publications

References 21 publications

Square-wave voltammetry of 5-fluorouracil

Square-wave voltammetry of 5-fluorouracil

Square-Wave Voltammetry of a Second Order Cathodic Stripping Process Coupled by Adsorption of the Reacting Ligand

Electrochemical Analysis of Nucleic Acids

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