“…The issue of dioxygen as interfering species is restricted not only to N 2 O, but also in the case of electrochemical detection of nitrate and nitrite, , where dioxygen scavenging is also key to successful sensor operation. Methods to remove dissolved dioxygen in amperometric applications include the usage of alkaline ascorbate solution, enzymes, sulfite, and thiosulfate, and by bacterial consumption in, e.g., NO x – /NO 2 – microsensors. , The techniques are, however, only applicable to aqueous solutions of the dioxygen scavenger. Additionally, since the polarization potential required for the electroreduction of N 2 O is also high enough to reduce water, the aqueous dioxygen scavenger must be situated in a chamber physically separated by a membrane. , The design of such a two-chamber sensor is shown in Figure (also see Figure S-1 in SI).…”