Polarographic evaluation of transmural oxygen availability in intact muscular arteries

In vivo oxygen transport in the normal rabbit femoral arterial wall.

“…Specifically, both prev ious in vivo studies from normal animals showed anl abrupt increase in oxygen current or Po2 over a short distance on traversing the region of the intimiia into arterial blood (8,9). Our profiles in this region were continuous, rising progressively to that of arterial blood as the wall was crossed from adventitia to lumen.…”

“…In 1968, Moss et al (8) used a sharply cut, bare platinum wire cathode (125 ,um diameter) for measurement of oxygen current in vivo in exposed dog femoral arteries. There was a progressive fall in current from adventitia toward intima, but an abrupt, essentially discontinuous, rise on entering the blood stream.…”

“…Subsequent in vitro measurements of wall oxygenation have not confirmed the presence of such a lbarrier (10,11). No transport theory modeling was uised in the in vivo studies of Moss et al (8) or Niinikoski et al (9) and in vivo oxygen consumptions were not calculated.…”

Report of the Hypertension Task Force of the National Heart, Lung, and Blood Institute. Current research and recommendations from the Subgroup on Local Hemodynamics.

“…28 The relative contribution of these sources varies in different arteries. 1 *"™ In the aorta, intramural vasa vasorum are present in significant numbers only in the outer layers.…”

“…In humans, cerebral blood flow remains normal in patients with established essential hypertension or toxemia of pregnancy. 28 8 In experimental animals, cerebral blood flow in SHR 188 and in renal hypertensive baboons 2 * 0 is normal. In contrast, cerebral blood flow has been reported decreased in stroke-prone SHR and in renal hypertensive rats.…”