Polarographic Analysis of Proteins, Amino Acids, and Other Compounds by Means of the Brdička Reaction

Müller, O.

doi:10.1002/9780470110294.ch8

Cited by 18 publications

(3 citation statements)

References 76 publications

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“…The investigation of the electrochemical properties of biological materials has gained a solid foundation over the past 80 years. From the very first observation of the protein electrochemical activity in polarographic measurements reported by Brdička in 1930s [ 186 , 187 , 188 ], great achievements [ 189 ] have been progressed in electrochemical studies of redox proteins, enzymes, and whole biological cells (e.g., bacterial cells, yeast cells, etc.). The success in bioelectrochemistry has been achieved by using carefully designed chemically modified electrode surfaces and particular experimental conditions [ 51 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Enzyme-Based Biosensors: Tackling Electron Transfer Issues

Bollella

Katz

2020

Sensors

110

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This review summarizes the fundamentals of the phenomenon of electron transfer (ET) reactions occurring in redox enzymes that were widely employed for the development of electroanalytical devices, like biosensors, and enzymatic fuel cells (EFCs). A brief introduction on the ET observed in proteins/enzymes and its paradigms (e.g., classification of ET mechanisms, maximal distance at which is observed direct electron transfer, etc.) are given. Moreover, the theoretical aspects related to direct electron transfer (DET) are resumed as a guideline for newcomers to the field. Snapshots on the ET theory formulated by Rudolph A. Marcus and on the mathematical model used to calculate the ET rate constant formulated by Laviron are provided. Particular attention is devoted to the case of glucose oxidase (GOx) that has been erroneously classified as an enzyme able to transfer electrons directly. Thereafter, all tools available to investigate ET issues are reported addressing the discussions toward the development of new methodology to tackle ET issues. In conclusion, the trends toward upcoming practical applications are suggested as well as some directions in fundamental studies of bioelectrochemistry.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Enzyme-Based Biosensors: Tackling Electron Transfer Issues

Bollella

Katz

2020

Sensors

110

View full text Add to dashboard Cite

show abstract

“…Its application in medical diagnostics made the relatively simple »Brdi~ka reaction« or »Brdi~ka test« widely known and used. [15][16][17][18][19][20][21][22] Nickel ions produce similar effects, though much weaker, under the same conditions. 23,24 Later on, it was repeatedly shown that cations of other metals, 25,26 and in buffers other than ammoniacal, 27,28 cause catalytic evolution of hydrogen in the presence of certain ligands.…”

Section: »Brdi~ka« Catalysismentioning

confidence: 99%