Polarized Microscopy in Lesions With Altered Dermal Collagen

Elbendary, Amira; Valdebran, Manuel; Parikh, Kruti; Elston, Dirk M.

doi:10.1097/dad.0000000000000550

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…These structures correlated histologically with increased collagen fibres arranged parallel to the epidermis, between the tumour and the epidermis, and the dissection of the collagen by spindle cells, causing irregular collagen distribution in the tumour. In the study of Elbendary and colleagues, it was found that the distribution, amount and structure of the collagen varied and they suggested that this might be the most important cause of birefringence in skin leading to different reflections in polarised microscopic examination. We also thought that white lines and clods were the result of interaction of polarised light with collagen, due to the birefringence phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic findings of Kaposi sarcoma and dermatopathological correlations

2019

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Background/Objective There are a limited number of studies regarding the dermoscopic features and dermatopathological correlations of Kaposi sarcoma. The primary objective of this study was to evaluate dermoscopic features of Kaposi sarcoma, and the secondary objective was to investigate their dermatopathological correlates. Methods Dermoscopic and clinical analysis of 222 lesions from 38 patients with histologically confirmed Kaposi darcoma were assessed by two investigators. A total of 83 biopsies were available from different clinical stages. Additionally, 3 mm punch biopsy was performed where newly defined dermoscopic findings were observed. Modified pattern analysis algorithm was used for the dermoscopic evaluation. Results The most common dermoscopic features of Kaposi sarcoma were white lines (55.9%) and white clods (37.8%) followed by surface scale (32.9%) and polychromatic colour change (22.1%). Four dot clods, white lines, white clods, collarette sign, serpentine vessels, dotted, curved and coiled vessels were the new dermoscopic findings of our study. Polychromatic colour change is correlated with the presence of hyaline globules probably with their birefringence properties, whereas we found no significant correlation between polychromatic colour change and honeycomb‐like pattern of vascular spaces. Conclusions White lines, white clods, four dot clods, collarette sign, serpentine vessels, dotted, curved and coiled vessels are the new dermoscopic features of Kaposi sarcoma, and polychromatic colour change is correlated with the presence of hyaline globules.

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Section: Discussionmentioning

confidence: 99%

Dermoscopic findings of Kaposi sarcoma and dermatopathological correlations

2019

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“…Dermatofibrosarcoma Protuberans is an extremely rare condition that can be confused with keloid, especially if growing to the size of 50 mm or not healing anyway ( 1 , 4 , 5 , 7 ). In such cases, a detailed investigation covers core biopsy and CT-imaging to achieve an exact tissue evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…Keloids are particularly bulging after a trauma in susceptible tissues, or in the color of the skin felt hard with anexamination or pinky red colored benign swelling ( 4 ). The method to be applied in the treatment is injection of suitable creams, injection into keloids, cryotherapy, radiotherapy and surgical treatment methods.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Misdiagnosis: Recurrence of Dermatofibrosarcoma Protuberans That Was Treated Surgicallyas a Keloid

Uçak¹

2018

Med Arch

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Aim: In this report, we presented the patient with Dermatofibrosarcoma Protuberans (DFSP), removed by considering as the keloid scar in the general surgery clinic with misdiagnosis.Case report: The patient was a 19-year-old female student with no scar or previous trauma history in the lesion area. Pathology report of excisional biopsy revealed as a DFSP, reachedsubcutis and dermis. In staging by CT, there had been no distant metastases. There was a lesion with the size of 2x1.5x1.5cm. A large resection was made to include the entire mass and the lower fascia. The defect area was repaired with a Limberg flap. There was no tumor recurrence in the first 6 months following the operation with high-level aesthetics for patient satisfaction. Conclusion: DFSP should be remembered in cases of operative or spontaneous keloid scarring lesions. The surgical treatment is possible after extensive resection with flap or graft repair.

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“…Due to its myriad functional role, collagen is widely accepted as an optical biomarker for diagnosis of various ailments including different types of cancer . Perturbation in dermal collagen synthesis or loss of excessive tissue collagen could lead to serious pathological conditions such as keloids and hypertrophic scars , liver cirrhosis , dermatofibroma , rheumatoid arthritis , lung fibrosis , morphea and dermal elastolysis . Importantly, the incidence of keloids and hypertrophic scar are more frequent in burn wounds causing physical damage, cosmetic disfigurement and a substantial amount of physiological stress affecting the quality of life .…”

Section: Discussionmentioning

confidence: 99%

Probing endogenous collagen by laser‐induced autofluorescence in burn wound biopsies: A pilot study

Prabhu

Acharya

Rao

et al. 2018

Journal of Biophotonics

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The focus of the current study was to interrogate the predictive potential of laser-induced autofluorescence (LIAF) by objectively assessing collagen synthesis in burn wound granulation tissues ex vivo. Prior grafting, granulation tissues (20 samples) following burn injury were collected from 17 subjects of age range 18 to 60 years with patient/donor consent and the corresponding autofluorescence spectra were recorded at 325 nm He-Cd laser (≈2 mW) excitations. The resulting endogenous collagen intensity from the above tissue samples was computed by normalizing the nicotinamide adenine dinucleotide levels. In addition, the hydroxyproline content was also estimated biochemically from the same granulation tissues. A comparative assessment of both LIAF and biochemical estimations for endogenous collagen by hydroxyproline resulted in strong positive correlation among them. The above relevant observations suggest that LIAF is equally informative as that of biochemical estimations, in evaluating endogenous collagen content in wound granulation tissues. Thus, it can be concluded that LIAF has the predictive potential, as a noninvasive objective tool to measure the endogenous collagen levels in wound biopsy tissues and provide complementary data conducive for making clinical decisions.

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Polarized Microscopy in Lesions With Altered Dermal Collagen

Cited by 8 publications

References 19 publications

Dermoscopic findings of Kaposi sarcoma and dermatopathological correlations

Dermoscopic findings of Kaposi sarcoma and dermatopathological correlations

A Rare Case of Misdiagnosis: Recurrence of Dermatofibrosarcoma Protuberans That Was Treated Surgicallyas a Keloid

Probing endogenous collagen by laser‐induced autofluorescence in burn wound biopsies: A pilot study

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