Polarized HLA Class I Expression on Renal Tubules Hinders the Detection of Donor-Specific Urinary Extracellular Vesicles
Liang Wu,
Martijn van Heugten,
Thierry van den Bosch
et al.
Abstract:Purpose
Kidney transplantation is the optimal treatment for patients with end-stage kidney disease. Donor-specific urinary extracellular vesicles (uEVs) hold potential as biomarkers for assessing allograft status. We aimed to develop a method for identifying donor-specific uEVs based on human leukocyte antigen (HLA) mismatching with the kidney transplant recipients (KTRs).
Patients and Methods
Urine and plasma were obtained from HLA-A2+ donors and HLA-A2- KTRs pre-trans… Show more
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