Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

Brill, Nicolai; Wirtz, Mathias; Merhof, Dorit; Tingart, Markus; Jahr, Holger; Truhn, Daniel; Schmitt, Robert; Nebelung, Sven

doi:10.1117/1.jbo.21.7.076013

Cited by 24 publications

(31 citation statements)

References 45 publications

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“…In dermatology PS-OCT has also been used to asses dermal photoageing [155], and for the identification and delineation of basal cell carcinoma [156]. In osteoarthritis, PS-OCT has been used for the assessment of cartilage [157][158][159][160][161].…”

Section: Dermatology Collagen and Nerves Cartilage And The Reduced mentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

350

241

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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Section: Dermatology Collagen and Nerves Cartilage And The Reduced mentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

350

241

View full text Add to dashboard Cite

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“…Similar observations have also been reported by others that the phase retardation in the deep area may accumulate relatively fast in some locations of cartilage samples. 15,26 However, in some other reported literature, 14,16,20 low birefringence has been found in deep zone at normal incidence. The difference in the results shows that the quantification of birefringence in the deep zone is quite sensitive, and it may depend on the types of samples, topographical locations, illumination angles, etc.…”

Section: Discussionmentioning

confidence: 87%

“…In Ref. 16, moderately degenerated cartilage samples were obtained from the central lateral femoral condyles of human patients. In an ideal model where the collagen fibers are aligned perfectly perpendicular to the tissue surface in the deep zone, the birefringence should be low in the deep zone when the incident light is exactly parallel with the fiber orientation under normal incidence.…”

Section: Discussionmentioning

confidence: 99%

“…15 Therefore, a more comprehensive quantitative method is needed to distinguish the different severities of DJD. Brill et al 16 quantified the features in the banding pattern of phase retardation image, such as the width and height of the bands and the total number of bands. Banding pattern appears when the phase retardation accumulates every π phase shift.…”

Section: Introductionmentioning

confidence: 99%

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Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

Zhou

Huang

et al. 2019

J. Biomed. Opt.

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A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method is validated on phantoms composed of layers of different materials. Articular cartilage samples from adult swine are segmented with the method. The characteristics in each segmented zone are also examined by histology and highresolution second-harmonic generation imaging, showing distinctive properties that match with the anatomical structure of articular cartilage. The segmentation algorithm is also applied on PS-OCT images acquired at multiple illumination angles, where the angular dependence of tissue birefringence in the deep zone is detected. This method offers a noninvasive imaging approach to differentiating the structural zones of articular cartilage, as well as a quantification approach based on the phase retardation measurements of PS-OCT. This method has great potential in studying depth-related progression of cartilage degeneration.

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“…Polarization-sensitive OCT (PSOCT), a functional extension of OCT, has been explored to study the alterations of structure-induced birefringence associated with early OA. [26][27][28] PSOCT obtains the images of phase retardation and optic axis using polarized incident light and polarization-sensitive detection. Although studies have shown the potential of PSOCT for revealing the loss of collagen (i.e., decease in birefringence) in damaged cartilage, 18,19,26,29 the usefulness of PSOCT for characterization of cartilage degeneration remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Parametric imaging of collagen structural changes in human osteoarthritic cartilage using optical polarization tractography

et al. 2017

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Collagen degeneration is an important pathological feature of osteoarthritis. The purpose of this study is to investigate whether the polarization-sensitive optical coherence tomography (PSOCT)-based optical polarization tractography (OPT) can be useful in imaging collagen structural changes in human osteoarthritic cartilage samples. OPT eliminated the banding artifacts in conventional PSOCT by calculating the depth-resolved local birefringence and fiber orientation. A close comparison between OPT and PSOCT showed that OPT provided improved visualization and characterization of the zonal structure in human cartilage. Experimental results obtained in this study also underlined the importance of knowing the collagen fiber orientation in conventional polarized light microscopy assessment. In addition, parametric OPT imaging was achieved by quantifying the surface roughness, birefringence, and fiber dispersion in the superficial zone of the cartilage. These quantitative parametric images provided complementary information on the structural changes in cartilage, which can be useful for a comprehensive evaluation of collagen damage in osteoarthritic cartilage.

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Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

Cited by 24 publications

References 45 publications

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization sensitive optical coherence tomography – a review [Invited]

Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

Parametric imaging of collagen structural changes in human osteoarthritic cartilage using optical polarization tractography

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