Polarization and permeability (quantitative measurements)

Ultraspectrophotometry of Cerebrospinal Fluids in Tumors of the Central Nervous System

“…W hile b rain. The above findings seem to confirm form er stu d ies (6) in w hich we com bined c o n d u c tiv ity , in te rfe ro m e try and chem ical d a ta and obtained evidence th a t, especially in b rain tu m o rs, th e ra tio of organic to inorganic co m pounds in the cerebrospinal fluid is in creased; even a fte r correctio n for p ro tein co n te n t th ere still was an increase of organic m a tte r.…”

“…mann, n u n g der L iq u o rv e rä n d e ru n g a n z u d eu ten . y a j N ach K o rre k tu r für V itam in C zeigen 7 5 % der T um o rliq u o ren 6. Spii E x tin k tio n sk o efficien ten ü b e r 0,8. w ährend n u r 8 % der K ontrollfälle Conf.…”

“…A lthough in tu m o rs of th e c e n tra l n e rv o u s sy ste m v a rio u s p a th o logic changes in the cereb ro sp in al fluid fre q u e n tly are o b serv ed (2) it seemed in te re stin g to look for re la tiv e ly c o n s ta n t an d c h a ra c teristic changes w hich m ay h a v e som e d ia g n o stic a l h earin g s. T e n ta tiv e studies (6) in d ic a ted t h a t cereb ro sp in a l fluids in 25 b ra in tu m o r cases show an increase o f y e t u n d efin ed o rg a n ic su b sta n c e s . In order to elucidate th e se p ro b lem s, m o re lu m b a r a n d v e n tric u la r fluids from p a tie n ts w ith tu m o rs o f th e c e n tra l n e rv o u s s y ste m were collected.…”

The Chemistry of Protein Denaturation.

“…(b) Organic solvents: Addition of alcohol or acetone to aqueous protein solutions causes denaturation, and coagulation in the region of the isoelectric point (68,367,386,409). This process is temperature dependent and does not seem to occur at a measurable rate at temperatures below -15°C.…”