Polarization and directed migration of murine neutrophils is dependent on cell surface expression of CD44

Alstergren, Per; Zhu, Baoqian; Glougauer, Michael; Mak, Tak W.; Ellen, Richard P.; Sodek, Jaro

doi:10.1016/j.cellimm.2005.01.007

Cited by 56 publications

(52 citation statements)

References 48 publications

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“…Several studies have shown a positive role of CD44 in inflammatory cell recruitment, 10,25,[36][37][38][39][40][41] whereas other investigations reported enhanced inflammatory cell migration in the absence of CD44. 8,9,24,35 This discrepancy is probably because of the differences in the cell type studied, the stimulus and organ involved, and the severity of the insult.…”

Section: Discussionmentioning

confidence: 93%

“…[8][9][10]24,25 In light of the important role of neutrophils and macrophages in host defense in pneumococcal pneumonia, 3 we determined the cellular composition of BALF harvested at 6, 24 or 48 h after infection with a lethal dose of S. pneumoniae (10 4 CFU). Whereas, macrophage numbers were similar in BALF harvested from CD44 KO and WT mice at all time points (data not shown), neutrophil counts were slightly enhanced at 6 h and more clearly at 24 h after infection, although these differences did not reach statistical significance (P ¼ 0.16 and P ¼ 0.06, respectively; Figure 3a).…”

Section: Cd44 Deficiency Results In Enhanced Early Neutrophilmentioning

confidence: 99%

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The role of CD44 in the acute and resolution phase of the host response during pneumococcal pneumonia

Windt

Hoogendijk

Vos

et al. 2011

Laboratory Investigation

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Streptococcus pneumoniae is the most prevalent pathogen causing community-acquired pneumonia. CD44 is a transmembrane adhesion molecule, expressed by a wide variety of cell types, that has several functions in innate and adaptive immune responses. In this study, we tested the hypothesis that CD44 is involved in the host response during pneumococcal pneumonia. On intranasal infection with a lethal dose of S. pneumoniae CD44-knockout (KO) mice showed a prolonged survival when compared with wild-type mice, which was accompanied by a diminished pulmonary bacterial growth and reduced dissemination to distant body sites. Whereas, proinflammatory cytokine responses and lung pathology were not affected, CD44 deficiency resulted in increased early neutrophil influx into the lung. In separate experiments, we confirmed a detrimental role of CD44 in host defense against pneumococci during sublethal pneumonia, as demonstrated by an improved capacity of CD44 KO mice to clear a low infectious dose. In addition, CD44 appeared important for the resolution of lung inflammation during sublethal pneumonia, as shown by histopathology of lung tissue slides. In conclusion, we show here that CD44 facilitates bacterial outgrowth and dissemination during pneumococcal pneumonia, which in lethal infection results in a prolonged survival of CD44 KO mice. Moreover, during sublethal pneumonia CD44 contributes to the resolution of the inflammatory response.

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Section: Discussionmentioning

confidence: 93%

Section: Cd44 Deficiency Results In Enhanced Early Neutrophilmentioning

confidence: 99%

The role of CD44 in the acute and resolution phase of the host response during pneumococcal pneumonia

Windt

Hoogendijk

Vos

et al. 2011

Laboratory Investigation

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“…CD44-/-neutrophils display impaired migration concerning direction and speed and reduced activation of RhoA [87]. Additionally CD44 ligation triggers neutrophil apoptosis in vitro [88].…”

Section: Physiological Function In Cells Of Hematopoietic Originmentioning

confidence: 98%

CD44 in hematological neoplasias

2011

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“…OPN has been found to play an important role in neutrophil recruitment in alcoholic liver disease (Apte et al, 2005;Banerjee et al, 2006). The expression and localization of CD44 in neutrophils is independent of OPN, although CD44 is required for the polarization and chemotaxis of neutrophils (Alstergren et al, 2004). Koh et al (2007) have demonstrated that OPN is important for the migration of neutrophils in vitro.…”

Section: Neutrophilsmentioning

confidence: 99%