Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage

Ozguldez, Hatice O.; Govindasamy, Niraimathi; Fan, Rui; Long, Hongyan; Mildner, Karina; Zeuschner, Dagmar; Trappmann, Britta; Ranga, Adrian; Bedzhov, Ivan

doi:10.1016/j.celrep.2023.112313

Cited by 7 publications

(1 citation statement)

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“…On one side of the embryo, a pool of polar TE cells inverts their apicobasal polarity at a tissue-scale level. This transition is caused by rapid cell proliferation and expansion of the visceral endodermal basal lamina, whose polarizing cues trigger the generation of an internal apical domain within the embryo and the disappearance of apical markers from the outward-facing TE cell membranes ( Ozguldez et al, 2023 ) ( Fig. 1B ).…”

Section: Inverted Polarity In Developmentmentioning

confidence: 99%

Inverted apicobasal polarity in health and disease

Pasquier,

Jaulin,

Peglion

2024

Journal of Cell Science

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Apicobasal epithelial polarity controls the functional properties of most organs. Thus, there has been extensive research on the molecular intricacies governing the establishment and maintenance of cell polarity. Whereas loss of apicobasal polarity is a well-documented phenomenon associated with multiple diseases, less is known regarding another type of apicobasal polarity alteration – the inversion of polarity. In this Review, we provide a unifying definition of inverted polarity and discuss multiple scenarios in mammalian systems and human health and disease in which apical and basolateral membrane domains are interchanged. This includes mammalian embryo implantation, monogenic diseases and dissemination of cancer cell clusters. For each example, the functional consequences of polarity inversion are assessed, revealing shared outcomes, including modifications in immune surveillance, altered drug sensitivity and changes in adhesions to neighboring cells. Finally, we highlight the molecular alterations associated with inverted apicobasal polarity and provide a molecular framework to connect these changes with the core cell polarity machinery and to explain roles of polarity inversion in health and disease. Based on the current state of the field, failure to respond to extracellular matrix (ECM) cues, increased cellular contractility and membrane trafficking defects are likely to account for most cases of inverted apicobasal polarity.

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Section: Inverted Polarity In Developmentmentioning

confidence: 99%