Polarity and viscosity-sensitive fluorescence probes for lipid droplet imaging in cancer cells

Aza-BODIPY-based polymeric nanoparticles for photothermal cancer therapy in a chicken egg tumor model

“…AZB-CF 3 exhibited weak uorescence signals in polar solvents, including, acetone, acetonitrile, and methanol, indicating a twisted intramolecular charge transfer (TICT) phenomenon upon excitation. 44,45 As the concentration of EtOH was increased in the hexane-EtOH systems, AZB-CF 3 likewise displayed a red shi in emission maxima as well as decreased uorescence, conrming the molecule's solvatochromic nature as a result of the TICT effect (Fig. 1C).…”

A wash-free fluorescent probe with a large Stokes shift for the identification of NAFL through tracing the change of lipid droplets

“…4,5 As a result, the dysfunction of LDs can give rise to a variety of diseases, including non-alcoholic fatty liver (NAFL), obesity, diabetes, atherosclerosis and many other serious diseases, which have a huge impact on human health. 6 In particular, mounting evidence confirms that the changes in number and size of LDs are closely related to NAFL since the dynamic variation can reflect the metabolic state of liver cells. 7,8 Thus, it is of great value to detect the LD state during the occurrence and progression of NAFL.…”

Dual-Functional AIE Fluorescent Probe for Visualization of Lipid Droplets and Photodynamic Therapy of Cancer

“…Lipid droplets (LDs), a type of dynamic organelle that acts as the repository of lipids, have a crucial impact on various vital movements including lipid traffic, signal transduction, formation of membranes, protein degradation, and so on. ,− Many aforementioned investigations have shown that the occurrence of cancers was closely related to abnormal LD levels, e.g., LDs in cancer cells were manifestly more in quantity when compared with the noncancer cells. − Hence, abnormalities in LDs have been established as key biomarkers for cancers. It is extremely essential to efficiently determine LDs for the clinical diagnosis and assessment of the therapy effect of relevant cancers.…”