Poisoning to α-pyrrolidinovalerophenone (α-PVP), a synthetic cathinone

A case of diffuse alveolar hemorrhage following synthetic cathinone inhalation

“…However, to our knowledge, there is no previously reported human case of DAH due to SC intoxication. [2][3][4][5][6] On the other hand, there are some case reports showing that poisoning with illicit drugs (e.g., amphetamine and cocaine) resulted in DAH. [7,8] The SCs that were inhaled by this case are phenylalkylamine derivatives producing an amphetamine-like effect; therefore, it is reasonable that SC intoxication can cause DAH.…”

“…[2,3] However cases of DAH following SC intoxication have not previously been reported. [2][3][4][5][6] We here present a 28-year-old man in hypoxic respiratory failure due to DAH. Although tests failed to identify the underlying cause of DAH, he recovered spontaneously and was discharged without any complications.…”

Interpol review of toxicology 2016–2019

“…Pyrovalerone derivatives type synthetic cathinones such as MPDV, α-PVP, α-PBP, α-PHP and α-PHPP have caused numerous reported deaths [ [289] , [290] , [291] , [292] , [293] , [294] , [295] , [296] ]. The detection and effect of MDPV (3,4-methylanedioxypyrovalerone) and α-PVP (α-pyrrolidinopentiophenone) on human were reviewed by Karila et al.…”

A Synthetic Cathinone -Alpha- pyrrolidinovalerophenone: Flakka

“…14 Avrupa Birliği tarafından 2010 yılına kadar hiçbir α-PVP vakası bildirimi yapılmamış iken, 2012 yılında 85 ve 2014 yılında 670 yakalama vakası bildirilmiştir. 15 Avrupa Birliği tarafından 2012-2015 yılları arasında yapılan toksikolojik analiz sonuçlarına göre 115 ölüm vakasında±-PVP'nin pozitif çıktığı rapor edilmiştir. Yirmi üç vakada ise α-PVP'nin doğrudan ölüm sebebi olduğu veya ölümün etkenlerinden biri olduğu kabul edilmiştir.…”