Poisoning due to Philodryas olfersii (Lichtenstein, 1823) attended at Restauração Hospital in Recife, State of Pernambuco, Brazil: case report

Correia, Juliana Mendes; Neto, Pedro de Lima Santana; Pinho, Milena Sardou Sabino; Silva, José Afrânio da; Amorim, Maria Lucineide Porto; Escobar, José Arturo Costa

doi:10.1590/s0037-86822010000300025

Cited by 28 publications

(28 citation statements)

References 5 publications

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“…Biochemical and pharmacological studies have also deepened our knowledge about rear-fanged snake venoms, and revealed that a number of species ( D. typus , Thelotornis capensis , Rhabdophis tigrinus , R. subminiatus , Balanophis ceylonensis , Philodryas olfersii , and Tachymenis peruviana ) are able to deliver lethal quantities of venoms and cause human fatalities [10], [12], [53], [100], [101], [102], [103], [104], [105], [106], [107]. Increasing awareness of life-threatening envenomings from rear-fanged snake bites should lead to an increased interest in research focused on these venoms, which in turn should contribute to prevent fatal human accidents, such as that unfortunately suffered by Karl Patterson Schmidt.…”

Section: Discussionmentioning

confidence: 99%

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

Plá

Sanz

Whiteley

et al. 2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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BackgroundNon-front-fanged colubroid snakes comprise about two-thirds of extant ophidian species. The medical significance of the majority of these snakes is unknown, but at least five species have caused life-threatening or fatal human envenomings. However, the venoms of only a small number of species have been explored.MethodsA combined venomic and venom gland transcriptomic approach was employed to characterise of venom of Dispholidus typus (boomslang), the snake that caused the tragic death of Professor Karl Patterson Schmidt. The ability of CroFab™ antivenom to immunocapture boomslang venom proteins was investigated using antivenomics.ResultsTranscriptomic-assisted proteomic analysis identified venom proteins belonging to seven protein families: three-finger toxin (3FTx); phospholipase A2 (PLA2); cysteine-rich secretory proteins (CRISP); snake venom (SV) serine proteinase (SP); C-type lectin-like (CTL); SV metalloproteinases (SVMPs); and disintegrin-like/cysteine-rich (DC) proteolytic fragments. CroFab™ antivenom efficiently immunodepleted some boomslang SVMPs.ConclusionsThe present work is the first to address the overall proteomic profile of D. typus venom. This study allowed us to correlate the toxin composition with the toxic activities of the venom. The antivenomic analysis suggested that the antivenom available at the time of the unfortunate accident could have exhibited at least some immunoreactivity against the boomslang SVMPs responsible for the disseminated intravascular coagulation syndrome that caused K.P. Schmidt's fatal outcome.General significanceThis study may stimulate further research on other non-front-fanged colubroid snake venoms capable of causing life-threatening envenomings to humans, which in turn should contribute to prevent fatal human accidents, such as that unfortunately suffered by K.P. Schmidt.

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Section: Discussionmentioning

confidence: 99%

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

Plá

Sanz

Whiteley

et al. 2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Experimental studies have shown that the Philodryas olfersii venom has hemorrhagic, proteolytic, fibrinogenolytic and fibrinolytic actions, but no anticoagulant action6. CORREIA et al 4 reported a case of Philodryas olfersii accident characterized by important local complications and anaphylactic reaction to the use of antibothropic serum, demonstrating that these accidents cannot be underestimated. Similarly, we observed one case of severe complications due to the bite of this snake, with the development of sepsis and AKI requiring dialysis.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Profile of Snakebite Accidents in a Metropolitan Area of Northeast Brazil

Albuquerque

Silva

Jacinto

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARY The aim of this study was to describe the epidemiological profile of snakebite accidents reported by the toxicological assistance center in Fortaleza, Ceará, Brazil. Database information on snakebite accidents was analyzed regarding the period from January 2003 to December 2011. A total of 1063 cases were found. The accidents occurred during the rainy months (March, April and May), in urban areas (52.3%), affecting individuals younger than 50 years and predominantly among males (70.7%). The lower limbs were the most frequently affected body area (33.7%). Most accidents involved non-venomous snakes (76.1%). The genus Bothrops was the main one involved in venomous accidents (83%). It is expected that this study can be used as the substrate to improve healthcare surveillance and implementing better measures for the treatment of this population.

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“…Espécie agressiva que tenta fugir ao toque, mas ao ser manuseada geralmente tenta morder, realiza descarga de substâncias de mau odor pela cloaca e debate-se vigorosamente. Acidentes provocados por P. olfersii são constantemente relatados na literatura (Fowler & Salomão, 1994;Ribeiro et al, 1999;Rocha & Furtado, 2007;Correia et al, 2010).…”

Section: Philodryas Olfersii (Lichtenstein 1823)unclassified

Ecologia e história natural das serpentes de uma área de Caatinga no nordeste brasileiro

Mesquita¹,

Passos²,

Borges-Nojosa³

et al. 2013

Pap. Avulsos Zool. (São Paulo)

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Poisoning due to Philodryas olfersii (Lichtenstein, 1823) attended at Restauração Hospital in Recife, State of Pernambuco, Brazil: case report

Abstract: Poisoning due to

Cited by 28 publications

References 5 publications

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

Epidemiological Profile of Snakebite Accidents in a Metropolitan Area of Northeast Brazil

Ecologia e história natural das serpentes de uma área de Caatinga no nordeste brasileiro

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