Points from Letters: Fetal malformation after Debendox treatment in early pregnancy

Menzies, Caitlin

doi:10.1136/bmj.1.6117.925-e

“…There have been isolated case reports of fetal malformations associated with Debendox (Donnai and Harris, 1978;Menzies, 1978;Frith, 1978) but in studies ofseries ofcases where the drug was taken there was no increased incidence of malformations (Harron et a/., 1980;Clarke and Clayton, 1981). Kohn and Parsons (1 978) and Redford and Lewis ( I 978) have described similar abnormalities when Debendox was not taken.…”

Section: Sirmentioning

confidence: 82%

Absence of fetal abnormality in one twin following large doses of Debendox

McGarry

¹

,

Bluett

²

,

Dawson

³

1982

Journal of Obstetrics and Gynaecology

1

0

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Birth Defects Monitoring

Klingberg

¹

,

Papier

²

,

Hart

³

1983

American J Industrial Med

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Population monitoring of birth defects provides a means for detecting relative changes in their frequency. Many varied systems have been developed throughout the world since the thalidomide tragedy of the early 1960s. Although it is difficult to pinpoint specific teratogenic agents based on rises in rates of a particular defect or a constellation of defects, monitoring systems can provide clues for hypothesis testing in epidemiological investigations. International coordination of efforts in this area resulted in the founding of the International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS) in 1974. In this paper we will describe the functions and basic requirements of monitoring systems in general, and look at the development and activities of the ICBDMS. A review of known and suspected environmental teratogenic agents (eg, chemical, habitual, biological, physical, and nutritional) is also presented.

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Birth defects monitoring

Klingberg¹,

Papier²,

Hart³

1983

View full text Add to dashboard Cite

Population monitoring of birth defects provides a means for detecting relative changes in their frequency. Many varied systems have been developed throughout the world since the thalidomide tragedy of the early 1960s. Although it is difficult to pinpoint specific teratogenic agents based on rises in rates of a particular defect or a constellation of defects, monitoring systems can provide clues for hypothesis testing in epidemiological investigations. International coordination of efforts in this area resulted in the founding of the International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS) in 1974. In this paper we will describe the functions and basic requirements of monitoring systems in general, and look at the development and activities of the ICBDMS. A review of known and suspected environmental teratogenic agents (eg, chemical, habitual, biological, physical, and nutritional) is also presented.

show abstract

Points from Letters: Fetal malformation after Debendox treatment in early pregnancy

Cited by 10 publications

References 0 publications

Absence of fetal abnormality in one twin following large doses of Debendox

Absence of fetal abnormality in one twin following large doses of Debendox

Birth Defects Monitoring

Birth defects monitoring

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