“…Hemoglobin (Hb) monitoring in patients undergoing home therapies is fundamental to increase overall quality of life and to prevent pathologies such as anemia, which may further exacerbate the overall clinical situation. To date, most of the POC solutions available in the literature and on the market aim to quantify hemoglobin in its glycated form [ 11 , 12 , 13 , 14 , 15 ] as a novel tool for diabetes early monitoring in a home setting. The gold standard for Hb quantification in patients is based on diverse methods, such as visual methods (Sahli’s, Dare, Haden, Wintrobe, Tallqvist), spectrophotometric methods (oxyhemoglobin, cyanmethemoglobin, gasometric, automated hemoglobinometry), or other methods (Alkaline-hematin, specific gravity, Lovibond comparator, copper-sulfate, HemoCue and automated hematology analyzers) [ 16 ].…”