Point-of-Care Instruments

Stern, Jere K.; Camus, Melinda S.

doi:10.1016/j.cvsm.2022.08.001

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…However, developing a reliable clinical test with a fast turnaround time is feasible. This is evidenced by many, once cumbersome and time-consuming, laboratory tests, that are now available as point-of-care tests 40 . Although such a platform does not yet exist for most metabolites measured here, several studies have shown reliable analyses with short turnaround times for amino acid concentrations 41 .…”

Section: Discussionmentioning

confidence: 97%

“…This is evidenced by many, once cumbersome and timeconsuming, laboratory tests, that are now available as point-ofcare tests. 40 Although such a platform does not yet exist for most metabolites measured here, several studies have shown reliable analyses with short turnaround times for amino acid concentrations. 41 Furthermore, microelectrode arrays allow second-by-second measures of glutamate that could be developed with organ viability assessment in mind.…”

Section: Discussionmentioning

confidence: 98%

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Ischemia-Induced Metabolic Patterns Associate With Kidney Function During Normothermic Kidney Perfusion, a Preclinical Study

De Beule,

De Craemer,

Verstraeten

et al. 2023

Annals of Surgery

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Objective: To investigate if ischemia alters donor kidney metabolism and whether these changes associate with organ function. Summary Background Data: An unmet need in kidney transplantation is the ability to predict post-transplant organ function before transplantation. Key to such viability testing is a profound understanding of the organ’s complex biochemistry and how ischemia, inevitable during the transplantation process, influences this. Methods: First, metabolic changes in glucose, lactate and 20 amino acids induced by no, 1h of warm, or 22h of cold ischemia were investigated during 4h perfusion of pig kidneys with autologous whole blood (n=6/group), simulating the ischemia-reperfusion phase of transplantation. Next, we confirmed similar metabolic changes during normothermic preservation of pig (n=3/group; n=4 for cold ischemia) and discarded human kidneys (n=6) perfused with a red-blood cell based perfusate. Results: At 2h of perfusion with autologous whole blood, abundances of 17/20 amino acids were significantly different between groups, reflecting the type of ischemia. Amino acid changes at 15 min and 2h of perfusion correlated with future kidney function during perfusion. Similar metabolic patterns were observed during perfusion preservation of pig and discarded human donor kidneys, suggesting an opportunity to assess kidney viability before transplantation. Conclusions: Perfusate metabolite changes during normothermic kidney perfusion represent a unique non-invasive opportunity to assess graft viability. These findings now need validation in transplant studies.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Ischemia-Induced Metabolic Patterns Associate With Kidney Function During Normothermic Kidney Perfusion, a Preclinical Study

De Beule,

De Craemer,

Verstraeten

et al. 2023

Annals of Surgery

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“…The capacity to discriminate between healthy and diseased patients is more difficult due to false positive testing and the trustworthiness of these examinations. Moreover, these methods take days to give findings that must be available immediately, in contrast to minutes for 'onsite' or point-of-care monitoring [33][34][35][36][37][38]. These intelligent technologies are able to identify physiological variations in the human body, offering a real-time response for a speedy medical choice.…”

Section: An Overview Of Sars-cov-2mentioning

confidence: 99%

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Ahmed,

Ansari,

Siddiqui

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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A critical step in the process for preventing and identifying emergencies relating to health, safety, and welfare is the testing and quick diagnosis of microbial pathogens. Due to the fast spread of waterborne and food borne infections in society and the high costs associated with them, pathogen identification has emerged as one of the most difficult parts of the water and food sectors. Since the turn of the century, pathogens have demonstrated enormous epidemiological and pandemic potential. The emergence and dissemination of a novel virus with pandemic potential endanger the livelihoods and well-being of individuals worldwide. The severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) coronavirus pandemic has propagated to almost every country on Earth and has had a considerable negative influence on economies and communities. Despite improvements in identification techniques for viral diseases, all nations must now execute biosensing in a speedy, sensitive, focused, and consistent manner in order to address pressing global issues. Hence, in this review, we have critically summarised the recent advancement of electrochemical as well as optical biosensors for the monitoring of SARS-COV-2 and various pathogens. Then, we began by providing a technical overview of cutting-edge strategies utilised to combat diseases and emergencies for it, including the utilisation of point-of-care technology (POCT), artificial intelligence (AI), and the internet of medical things (IoMT). This review article explores the integration of POC, IoMT, and AI technologies in the context of personal healthcare, focusing on their potential to expedite the diagnosis and treatment of medical conditions, ultimately leading to improved patient outcomes. Subsequently, the notion and execution of multiplex testing are presented to enhance the comprehension of detecting multiple analytes. Finally, conclusions and future directions have been presented.

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“…Point-of-care analyzers are becoming the new standard for the quick and precise assessment of important physiological parameters in human as well as veterinary medicine ( Lubba et al, 2011 ; Park, 2021 ; Stern & Camus, 2022 ). For field biologists, ecologists, and conservationists this is a great leap forward as these devices allow monitoring of blood metabolites directly in the field and making a first assessment of the overall clinical and health status of wild individuals and populations at risk of extinction.…”

Section: Introductionmentioning

confidence: 99%

Hand grab or noose pole? Evaluating the least stressful practice for capture of endangered Turks and Caicos Rock Iguanas Cyclura carinata

Colosimo,

Montemuro,

Lewbart

et al. 2024

PeerJ

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As the analysis of blood metabolites has become more readily accessible thanks to the use of point-of-care analyzers, it is now possible to evaluate stress level of wild animals directly in the field. Lactate is receiving much attention as a good stress level proxy in individuals subjected to capture, manual restraint, and data sampling in the wild, and appropriate protocols to maintain lactate values low should be preferred. In this study we compare how two different capture methodologies, hand grab vs. noose pole, affect the variation of blood lactate values in Cyclura carinata iguanas when captured for sampling. We used blood lactate concentration, measured immediately upon- and 15 min after-capture, as a proxy for stress level. While the primary goal of this work is to determine the least stressful capture methodology to be favored when sampling this and other wild iguanas, we also evaluated additional baseline physiological parameters relevant to the health and disease monitoring for this species. Our results show that while initial lactate values level-out in sampled individuals after 15 min in captivity, regardless of the capture methodology, rock iguanas captured by noose pole showed significantly higher lactate concentration and increased heartbeat rate immediately after capture. While the overall health evaluation determined that all analyzed individuals were in good health, based on our results we recommend that, when possible, hand capture should be preferred over noose pole when sampling wild individuals.

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Point-of-Care Instruments

Cited by 5 publications

References 17 publications

Ischemia-Induced Metabolic Patterns Associate With Kidney Function During Normothermic Kidney Perfusion, a Preclinical Study

Ischemia-Induced Metabolic Patterns Associate With Kidney Function During Normothermic Kidney Perfusion, a Preclinical Study

Electrochemical and optical-based systems for SARS-COV-2 and various pathogens assessment

Hand grab or noose pole? Evaluating the least stressful practice for capture of endangered Turks and Caicos Rock Iguanas Cyclura carinata

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