Point-of-care COVID-19 testing in the emergency department: current status and future prospects

May, Larissa; Tran, Nam K.; Ledeboer, Nathan A.

doi:10.1080/14737159.2021.2005582

Cited by 13 publications

(14 citation statements)

References 43 publications

(43 reference statements)

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“…Rapid triage of patients with suspected COVID-19 is a key aspect for preventing ED overcrowding and delivering the best possible care to the patients [ 24 ]. Over two years after COVID-19 has been declared pandemic, a huge number of clinical laboratories are still facing enormous challenges to provide timely test results of SARS-CoV-2 testing and, even worse, cannot provide reliable solutions to facilitate fast and accurate diagnosis that is required in acute care and short-stay hospital units [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

FebriDx for rapid screening of patients with suspected COVID-19 upon hospital admission: systematic literature review and meta-analysis

Lippi

Nocini

Mattiuzzi³

et al. 2022

Journal of Hospital Infection

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Section: Discussionmentioning

confidence: 99%

FebriDx for rapid screening of patients with suspected COVID-19 upon hospital admission: systematic literature review and meta-analysis

Lippi

Nocini

Mattiuzzi³

et al. 2022

Journal of Hospital Infection

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“…It is obvious that a short turnaround time can potentially improve patient care and outcomes by providing quick access to test results, expediting medical diagnosis, and facilitating earlier and more rapid decisions on treatment. 1 , 2 Another benefit of POCT is that it can be performed by clinical staff without laboratory training. POCT can be done at a healthcare provider's office, outpatient clinic, emergency room, and healthcare nursing home.…”

Section: The Studymentioning

confidence: 99%

Clinical evaluation of the Cue's COVID‑19 diagnostic test to detect SARS‐CoV‐2 in the upper respiratory tract

Phan

Cravener

McCullough

et al. 2022

Journal of Medical Virology

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Point-of-care testing (POCT) known as near-patient testing has a relatively lower cost and short turnaround time. It is obvious that a short turnaround time can potentially improve patient care and outcomes by providing quick access to test results, expediting medical diagnosis, and facilitating earlier and more rapid decisions on treatment. 1,2 Another benefit of POCT is that it can be performed by clinical staff without laboratory training. POCT can be done at a healthcare provider's office, outpatient clinic, emergency room, and healthcare nursing home. 3,4 More than 2 years into the COVID-19 | 3517 Donato and colleagues performed the prospective study in the outpatient setting, and the Ct value or viral load of the positive specimens was random. 11 Our positive specimens were carefully selected to verify the lower sensitivity, and a majority of them (61.1%, 11 of 18) had high Ct values (>30.0). In our evaluation, the clinical performance of the Cue's COVID-19 test started to decline as the Ct values increased reflecting decreasing viral loads. This phenomenon was also observed in other rapid NAAT POCTs such as the ID NOW COVID-19 test which has the lower performance for specimens displaying the Ct value higher than 30.0. 12 Given the persistence of the SARS-CoV-2 testing backlog, low availability of testing supply, and shortage of licensed personnel in clinical laboratories, we need to migrate more testing capacity to the outpatient setting and the Cue's COVID-19 test is a good option. AUTHOR CONTRIBUTIONS Tung Phan and Alan Wells designed the study and wrote the manuscript. Zachary Cravener, Melissa McCullough, Ashley Mays, and Jamie Gribschaw managed the testing.

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“…To overcome the limitations of the molecular diagnosis of SARS-CoV-2, multiple diagnostic methods have been developed and studied, including the rapid antigen test (RAT) [4,5]. An antigen test is an immunoassay that detects the presence of a specific Diagnostics 2022, 12, 710 2 of 11 viral antigen, which implies current viral infection.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Diagnostic Accuracy of Nasal Cavity and Nasopharyngeal Swab Specimens for SARS-CoV-2 Detection via Rapid Antigen Test According to Specimen Collection Timing and Viral Load

et al. 2022

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The rapid diagnosis of SARS-CoV-2 is an essential aspect in the detection and control of the spread of COVID-19. We evaluated the accuracy of the rapid antigen test (RAT) using samples from the nasal cavity and nasopharynx based on sample collection timing and viral load. We enrolled 175 patients, of which 71 patients and 104 patients had tested positive and negative, respectively, based on real time-PCR. Nasal cavity and nasopharyngeal swab samples were tested using STANDARD Q COVID-19 Ag tests (Q Ag, SD Biosensor, Korea). The sensitivity of the Q Ag test was 77.5% (95% confidence interval [CI], 67.8–87.2%) for the nasal cavity and 81.7% (95% [CI, 72.7–90.7%) for the nasopharyngeal specimens. The RAT results showed a substantial agreement between the nasal cavity and nasopharyngeal specimens (Cohen’s kappa index = 0.78). The sensitivity of the RAT for nasal cavity specimens exceeded 89% for <5 days after symptom onset (DSO) and 86% for Ct of E and RdRp < 25. The Q Ag test performed fairly well, especially in the early DSO when a high viral load was present, and the nasal cavity swab can be considered an alternative site for the rapid diagnosis of COVID-19.

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Point-of-care COVID-19 testing in the emergency department: current status and future prospects

Cited by 13 publications

References 43 publications

FebriDx for rapid screening of patients with suspected COVID-19 upon hospital admission: systematic literature review and meta-analysis

FebriDx for rapid screening of patients with suspected COVID-19 upon hospital admission: systematic literature review and meta-analysis

Clinical evaluation of the Cue's COVID‑19 diagnostic test to detect SARS‐CoV‐2 in the upper respiratory tract

Evaluation of the Diagnostic Accuracy of Nasal Cavity and Nasopharyngeal Swab Specimens for SARS-CoV-2 Detection via Rapid Antigen Test According to Specimen Collection Timing and Viral Load

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