Abstract:Neomycin, aminoglycoside antibiotics with broad-spectrum antibacterial resistance, is widely used in pharmaceutical and agricultural fields. However, the separation and purification process of neomycin B as an active substance is complicated in Streptomyces fradiae. Although NeoN can catalyze neomycin C to generate neomycin B, the catalytic mechanism of NeoN is still unclear. In this study, whole genomics sequencing clarified the genomic information of high-yielding mutant SF-2. Subsequently, the mechanism of … Show more
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