Point Decoration of Silicon Nanowires: An Approach Toward Single‐Molecule Electrical Detection

Wang, Jindong; Shen, Fangxia; Wang, Zhenxing; He, Gen; Qin, Jinwen; Cheng, Nongyi; Yao, Maosheng; Li, Lidong; Guo, Xuefeng

doi:10.1002/ange.201309438

Cited by 19 publications

(14 citation statements)

References 79 publications

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“…One‐dimensional silicon nanowires (SiNWs), whose conductance is strongly dependent on the local charge density, were shown to be high‐gain field‐effect sensors that are able to detect chemical or biological species in solution . Recently, by rationally incorporating individual point scattering sites into SiNW field‐effect transistors (FETs), we developed a direct, real‐time electrical approach of sensing intermolecular interactions in biological systems with single‐molecule sensitivity . In this study, we take advantage of such a field‐effect‐based single‐molecule methodology to achieve measurements of hairpin hybridization kinetics with sufficiently high signal‐to‐noise ratio and bandwidth that are able to reveal the dynamic folding/unfolding process of a single hairpin DNA at the single base‐pair level.…”

Section: Figuresupporting

confidence: 84%

Direct Measurement of Single‐Molecule DNA Hybridization Dynamics with Single‐Base Resolution

et al. 2016

Angew Chem Int Ed

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Herein, we report label-free detection of single-molecule DNA hybridization dynamics with single-base resolution. By using an electronic circuit based on point-decorated silicon nanowires as electrical probes, we directly record the folding/unfolding process of individual hairpin DNAs with sufficiently high signal-to-noise ratio and bandwidth. These measurements reveal two-level current oscillations with strong temperature dependence, enabling us to determine the thermodynamic and kinetic properties of hairpin DNA hybridization. More importantly, successive, stepwise increases and decreases in device conductance at low temperature on a microsecond timescale are successfully observed, indicating a base-by-base unfolding/folding process. The process demonstrates a kinetic zipper model for DNA hybridization/dehybridization at the single base-pair level. This measurement capability promises a label-free single-molecule approach to probe biomolecular interactions with fast dynamics.

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Section: Figuresupporting

confidence: 84%

Direct Measurement of Single‐Molecule DNA Hybridization Dynamics with Single‐Base Resolution

et al. 2016

Angew Chem Int Ed

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“…bottom-up molecular electronics. 2 , 9 , 10 Moreover, stable, covalently modified oxide-free Si surfaces have many applications in the immobilization and detection of biomolecules, 11 − 13 offer a platform on which fundamental physical and chemical processes such as electron transfer and reactivity can be studied, 14 and are useful in molecular catalysis. 15 …”

Section: Introductionmentioning

confidence: 99%

High-Density Modification of H-Terminated Si(111) Surfaces Using Short-Chain Alkynes

et al. 2017

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H–Si(111)-terminated surfaces were alkenylated via two routes: through a novel one-step gas-phase hydrosilylation reaction with short alkynes (C3 to C6) and for comparison via a two-step chlorination and Grignard alkenylation process. All modified surfaces were characterized by static water contact angles and X-ray photoelectron spectroscopy (XPS). Propenyl- and butenyl-coated Si(111) surfaces display a significantly higher packing density than conventional C10–C18 alkyne-derived monolayers, showing the potential of this approach. In addition, propyne chemisorption proceeds via either of two approaches: the standard hydrosilylation at the terminal carbon (lin) at temperatures above 90 °C and an unprecedented reaction at the second carbon (iso) at temperatures below 90 °C. Molecular modeling revealed that the packing energy of a monolayer bonded at the second carbon is significantly more favorable, which drives iso-attachment, with a dense packing of surface-bound iso-propenyl chains at 40% surface coverage, in line with the experiments at <90 °C. The highest density monolayers are obtained at 130 °C and show a linear attachment of 1-propenyl chains with 92% surface coverage.

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“…No doubt, single-molecule electronics (molecular electronics) that involves the action of electrodes with a single molecule in between them represents the ultimate limit of miniaturization of electronic devices (Sun et al 2014;Kima et al 2014). However, largescale fabrication of fully functional single molecule electronic circuit is still far from reality, although some significant development has been achieved with respect to the construction of meta-molecule-metal junctions that includes the use of nanowires (Cobden 2001;Wang et al 2014;Dasgupta et al 2014), nanotubes (Sorgenfrei et al 2011;Liu et al 2010), nanogaps (Du et al 2009Yaghmaie et al 2010), nanopores (Howorka and Siwy 2009;Arjmandi-Tash et al 2016;Lagerqvist et al 2006), mechanical break junctions (Xu et al 2003;Zhao et al 2014), mechanical cantilevers (Burg et al 2007), electromigration (Park et al 1999), electron beam lithography (Nicewarner-Pena et al 2001;Qin et al 2005), molecular rulers (Hatzor and Weiss 2001;Dadosh et al 2005), scanning tunneling microscopy (STM) , atomic force microscopy (AFM) (Xu et al 2003;Sader et al 2005), and others. Studying the single molecule electronic circuits is extremely important in understanding the transport behavior at a single-molecule level in order to prepare entirely molecular integrated circuits (Cui et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Conductance through glycine in a graphene nanogap

et al. 2018

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We report theoretical analysis of charge transport process through a single glycine molecule utilizing graphene nanogaps. Density functional theory and non-equilibrium Green's function method are employed to investigate the transport properties of glycine inside the gap. The projected density of states, transmittance, and the current-voltage characteristics are determined with changes in the molecular orientation inside the nanogap of c.a 0.8 nm. The current

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Point Decoration of Silicon Nanowires: An Approach Toward Single‐Molecule Electrical Detection

Cited by 19 publications

References 79 publications

Direct Measurement of Single‐Molecule DNA Hybridization Dynamics with Single‐Base Resolution

Direct Measurement of Single‐Molecule DNA Hybridization Dynamics with Single‐Base Resolution

High-Density Modification of H-Terminated Si(111) Surfaces Using Short-Chain Alkynes

Conductance through glycine in a graphene nanogap

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