Poikilodermatous Mycosis Fungoides and Atrophic Large-Plaque Parapsoriasis Exhibit Similar Abnormalities of T-Cell Antigen Expression

Lindae, Mary L.; Abel, Elizabeth A.; Hoppe, Richard T.; Wood, Gary S.

doi:10.1001/archderm.1988.01670030032018

Cited by 41 publications

(10 citation statements)

References 14 publications

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“…49 It seems likely that architectural abnormalities (infiltrate, epidermotropism) are more important than cytologic atypia for the diagnosis of early lesions of MF. 18,19,31,36,37,48 We observed in a high percentage of cases (59%) focal changes of interface dermatitis, mostly in the absence of poikilodermatous changes. 4,12,56 A vacuolar degeneration of basal keratinocytes is well known in poikilodermatous MF.…”

Section: Discussionmentioning

confidence: 80%

Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides

Massone¹,

Kodama²,

Kerl³

et al. 2005

American Journal of Surgical Pathology

174

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The histologic diagnosis of early mycosis fungoides (MF) is one of the most vexing problems in dermatopathology. We reviewed the histopathologic features of 745 biopsy specimens from 427 patients (male:female = 277:150; median age, 52 years; range, 3-95 years) with early (patch) lesions of MF collected from the lymphoma database of the Department of Dermatology of the Medical University of Graz (Austria). In all patients, the diagnosis was established by clinicopathologic correlation. The most common histopathologic pattern consisted of a band-like or patchy lichenoid infiltrate admixed with coarse bundles of collagen in the superficial dermis. Epidermotropism of lymphocytes was observed in most cases in one or more forms (single lymphocyte epidermotropism, 22%; basilar lymphocytes, 23%; Pautrier's microabscesses, 19%; "haloed" lymphocytes, 40%; disproportionate exocytosis, 17%; pagetoid epidermotropism, 3%). In 4% of cases, epidermotropism was completely missing. Atypical lymphocytes were present only in 9% of cases. Features of interface dermatitis were observed in 59% of cases. Other unusual findings were the presence of necrotic keratinocytes (23%), melanophages (8%), and extravasated erythrocytes (4%). In 28 patients, two or more biopsies taken on the same day at different body sites showed different histopathologic aspects, underlying the protean features of MF even in a single patient at a given time. Our study expands previous observations on histopathologic features of early lesions of MF. Although sometimes the histopathologic features are not diagnostic, they should be considered consistent with MF and do not rule out the diagnosis.

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Section: Discussionmentioning

confidence: 80%

Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides

Massone¹,

Kodama²,

Kerl³

et al. 2005

American Journal of Surgical Pathology

174

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“…[7][8][9] It has been reported that CD8 positive MF follows a more aggressive course if the neoplastic cells are CD2 negative and CD7 positive. [10] A recent study on prognostic implications of marker studies in MF done by Massone et al, [11] reports lack of significance of marker studies in determining the prognosis of MF.…”

Section: Discussionmentioning

confidence: 99%

A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides

Khopkar¹,

Doshi²,

Dongre³

et al. 2011

Indian J Dermatol Venereol Leprol

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“…CD7 is by far the most commonly reported T-cell antigen to be lost in MF; however, it is also the least specific because CD7 is observed to be lost in many inflammatory skin conditions. [15][16][17] Decreased expression of CD2 or CD5 has been described as very specific but relatively insensitive for MF; for example, a recent study by Furmanczyk et al 18 observed sensitivity and specificity of 22% and 100%, respectively, for decreased expression of CD2 or CD5 in epidermal T cells. 18 Other investigators observed similarly low sensitivity for decreased expression of CD2, CD3, and CD5.…”

Section: Discussionmentioning

confidence: 99%

Immunophenotypic Correlation Between Skin Biopsy and Peripheral Blood Findings in Mycosis Fungoides

Kelemen

White

Gatter

et al. 2010

American Journal of Clinical Pathology

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In mycosis fungoides (MF) with blood involvement, T-cell immunophenotypes in skin and blood have not been compared. Our aim was to evaluate T-cell immunophenotypes in skin by immunohistochemical analysis and compare results with flow cytometric (FC) findings in blood. Of 20 patients with MF with blood involvement, the immunophenotype was discrepant in 11 (55%). Compared with FC findings in blood, immunohistochemical analysis of skin samples failed to detect partial deletion of CD2 (5/11 [45%]), CD3 (3/11 [27%]), and CD5 (3/11 [27%]) and overrepresented deletion of CD7 in 2 (18%) of 11 patients. In addition, CD8+ MF was missed by immunohistochemical analysis in 2 (18%) of 11 patients. Identical T-cell populations were demonstrated by T-cell gene polymerase chain reaction in skin and blood in 8 of the 11 patients who had a discrepant immunophenotype. Awareness of the limitations of immunohistochemical analysis of skin samples is of practical value for pathologists interpreting skin biopsies in MF patients. In addition, our findings suggest CD8+ MF to be more common than previously reported.

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Poikilodermatous Mycosis Fungoides and Atrophic Large-Plaque Parapsoriasis Exhibit Similar Abnormalities of T-Cell Antigen Expression

Cited by 41 publications

References 14 publications

Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides

Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides

A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides

Immunophenotypic Correlation Between Skin Biopsy and Peripheral Blood Findings in Mycosis Fungoides

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