Abstract:Characterized by mixed hypo‐ and hyperpigmentation, skin atrophy and telangiectasia, poikiloderma is a feature of a number of different genetic skin diseases including dyskeratosis congenita, Rothmund–Thomson syndrome, Kindler syndrome and poikiloderma with neutropenia. Systemic associations of these disorders may include developmental abnormalities, a predisopsition to malignancy or infection, or progressive fibrosis of the bone marrow and other organs. Clinical and, where possible, genetic evaluation are vit… Show more
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