Podophyllotoxin

Sullivan, M. X.

doi:10.1001/archderm.1949.01530010004001

Cited by 14 publications

(2 citation statements)

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“…Furthermore, an antiviral effect of podophyllotoxin has also been demonstrated. [ 14 ] Various structure-activity relationship studies on several podophyllotoxin analogs have shown that the core structure of deoxy podophyllotoxin is responsible for cytotoxicity. [ 15 ]…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Podophyllin in dermatology: Revisiting a historical drug

Singh

Choudhary

Ganguly

2022

Indian Dermatol Online J

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Podophyllin is a cytotoxic material extracted from Podophyllum peltatum and Podophyllum hexandrum and is widely used for the treatment of genital warts. This article reviews the chemistry of podophyllin and its active components along with the mechanism of action in various dermatoses. Furthermore, the documented uses of podophyllin in various dermatological disorders have been described along with the side effects of the drug. Based on the available literature, a clinical guideline is being proposed so as to minimize the side effects. Further studies should be carried out on its use in a lower concentration in other dermatoses, especially premalignant and malignant skin diseases.

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Section: Mechanism Of Actionmentioning

confidence: 99%

Podophyllin in dermatology: Revisiting a historical drug

Singh

Choudhary

Ganguly

2022

Indian Dermatol Online J

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“…3 The self -administration of 0.15 -0.5% purifi ed podophyllotoxin (podofi lox) preparations applied twice daily for 3 days is a safe alternative for the treatment of condyloma acuminatum compared with the use of nonstandardized USP podophyllum resin. USP Podophyllum resin is an alcohol extract of the dried rhizomes and roots of Podophyllum peltatum used to treat condyloma acuminatum in the United States since 1942.…”

Section: Exposurementioning

confidence: 99%

Mayapple (Podophyllum peltatumL.)

Barceloux

2008

Medical Toxicology of Natural Substances

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Sur quelques constituants de la podophylline et sur la structure de la podophyllotoxine, de l'α‐peltatine et de la β‐peltatine

Brun

1954

Helvetica Chimica Acta

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Nous avons pu isoler à l'état cristallisé quatre constituants de l'extrait autolysé de rhizome de Podophyllum peltatum L.: la podophyllotoxine, la β‐peltatine, l'α‐peltatine et la picro‐α‐peltatine. Les formules globales que nous avons trouvées, à part la formule de la picro‐α‐peltatine, ne correspondent pas à celles indiquées par d'autres auteurs. Nous proposond des formules de constitution pour ces substances.

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Podophyllotoxin

Cited by 14 publications

References 0 publications

Podophyllin in dermatology: Revisiting a historical drug

Podophyllin in dermatology: Revisiting a historical drug

Mayapple (Podophyllum peltatumL.)

Sur quelques constituants de la podophylline et sur la structure de la podophyllotoxine, de l'α‐peltatine et de la β‐peltatine

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