Podophyllotoxin and Antitumor Synthetic Aryltetralines. Toward a Biomimetic Preparation

Bruschi, Maurizio; Orlandi, Marco; Rindone, Michol; Rindone, Bruno; Saliu, Francesco; Suarez-Bertoa, Ricardo; Tollpa, Eva Liisa; Zoia, Luca

doi:10.5772/8772

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Phenolic Compounds1

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Cited by 2 publications

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“…Podophyllotoxin (Figure 3) has long been known to possess anti-mitotic activity with early clinical trials indicating its high efficacy. Unfortunately, this compound is known to be toxic limiting its direct application as a drug [12]. To solve the problem of toxicity, several modifications were made to the podophyllotoxin structure in hope of obtaining compounds with low toxicity but retain the desired activities of the parent compound.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Nanoflora — How Nanotechnology Enhanced the Use of Active Phytochemicals

Odeh¹,

Al‐Jaber²,

Khater³

2014

Application of Nanotechnology in Drug Delivery

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Section: Phenolic Compoundsmentioning

confidence: 99%

Nanoflora — How Nanotechnology Enhanced the Use of Active Phytochemicals

Odeh¹,

Al‐Jaber²,

Khater³

2014

Application of Nanotechnology in Drug Delivery

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Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division

Zulkipli

David

Rajabalaya

et al. 2015

Drug Target�Insights

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Modern medicinal plant drug discovery has provided pharmacologically active compounds targeted against a multitude of conditions and diseases, such as infection, inflammation, and cancer. To date, natural products from medicinal plants remain a solid niche as a source from which cancer therapies can be derived. Among other properties, one favorable characteristic of an anticancer drug is its ability to block the uncontrollable process of cell division, as cancer cells are notorious for their abnormal cell division. There are numerous other documented works on the potential anticancer activity of drugs derived from medicinal plants, and their effects on cell division are an attractive and growing therapeutic target. Despite this, there remains a vast number of unidentified natural products that are potentially promising sources for medical applications. This mini review aims to revise the current knowledge of the effects of natural plant products on cell division.

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Podophyllotoxin and Antitumor Synthetic Aryltetralines. Toward a Biomimetic Preparation

Cited by 2 publications

References 48 publications

Nanoflora — How Nanotechnology Enhanced the Use of Active Phytochemicals

Nanoflora — How Nanotechnology Enhanced the Use of Active Phytochemicals

Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division

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