Podocyte-targeted therapies — progress and future directions

Meliambro, Kristin; He, John C.; Campbell, Kirk N.

doi:10.1038/s41581-024-00843-z

Nat Rev Nephrol

2024

DOI: 10.1038/s41581-024-00843-z

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Podocyte-targeted therapies — progress and future directions

Kristin Meliambro,

John C. He,

Kirk N. Campbell

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2024

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Cited by 2 publications

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Kidney Disease and Antinephrin Antibodies

Reiser,

Ingelfinger

2024

N Engl J Med

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Kidney Disease and Antinephrin Antibodies

Reiser,

Ingelfinger

2024

N Engl J Med

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Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets

Zhong,

Wang,

Zhang

2024

IJMS

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Cell deaths maintain the normal function of tissues and organs. In pathological conditions, the abnormal activation or disruption of cell death often leads to pathophysiological effects. Diabetic kidney disease (DKD), a significant microvascular complication of diabetes, is linked to high mortality and morbidity rates, imposing a substantial burden on global healthcare systems and economies. Loss and detachment of podocytes are key pathological changes in the progression of DKD. This review explores the potential mechanisms of apoptosis, necrosis, autophagy, pyroptosis, ferroptosis, cuproptosis, and podoptosis in podocytes, focusing on how different cell death modes contribute to the progression of DKD. It recognizes the limitations of current research and presents the latest basic and clinical research studies targeting podocyte death pathways in DKD. Lastly, it focuses on the future of targeting podocyte cell death to treat DKD, with the intention of inspiring further research and the development of therapeutic strategies.

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Podocyte-targeted therapies — progress and future directions

Cited by 2 publications

References 292 publications

Kidney Disease and Antinephrin Antibodies

Kidney Disease and Antinephrin Antibodies

Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets

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