Po-703-02 Digital Health Device Demonstrates the Long-Term Impact of Covid-19 on the Cardiovascular and Autonomic System

DAGHER, Lilas; Hajjar, Abdel Hadi El; Mekhael, Mario; Noujaim, Charbel; ayoub, Tarek; LI, Dan L.; Lim, Chan Ho; Marrouche, Nassir F.

doi:10.1016/j.hrthm.2022.03.1056

Cited by 1 publication

(5 citation statements)

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“…The last one was excluded because the study did not report HRV parameters [ 36 ]. Finally, 11 studies in 12 documents [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] were included in this review, of which, Mekhael et al [ 45 ] (journal article) and Dagher et al [ 48 ] (conference abstract) reported different outcomes for the same study. In dealing with these two documents, we described characteristics and assessed methodological quality based on Mekhael et al [ 45 ], but we extracted HRV parameters from Dagher et al [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies had a cross-sectional design. Of the 11 included studies (except for Dagher et al [ 48 ]), 10 were published as journal articles [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ], and 1 was presented as a conference abstract [ 37 ]. Two studies were conducted in the USA [ 37 , 45 ], Italy [ 38 , 47 ], Turkiye [ 40 , 42 ], and Brazil [ 41 , 44 ]; the remaining studies were conducted in Spain [ 39 ], China [ 43 ], and India [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on the findings, the authors suggested that damage to the heart or ANS caused by SARS-CoV-2 infection could be long-lasting. Mekhael et al [ 45 ] (the HRV data extracted from Dagher et al [ 48 ]) compared individuals with previous COVID-19 infection at 171 ± 114 days and controls who were not diagnosed with COVID-19. They found a significant decrease in mean HRV (ms) in the study group (38.9 ± 614.4 vs. 44.0 ± 619.2, p = 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…This systematic review investigated the long-term effect of COVID-19 on HRV parameters. Eleven cross-sectional studies in 12 references [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] were included by systematic and comprehensive search. This review broadly divided studies under three population conditions: individuals with long COVID (i.e., symptomatic); post-COVID-19 individuals without long COVID (i.e., asymptomatic); and individuals whose presence of long COVID was uncertain (i.e., unclear).…”

Section: Discussionmentioning

confidence: 99%

“…However, this result contrasts with findings from most other studies included in this review [ 37 , 38 , 41 , 42 , 43 , 46 ]. Third, changes in HRV parameters of individuals whose presence of long COVID is uncertain were investigated in seven studies in eight documents [ 37 , 41 , 42 , 43 , 45 , 46 , 47 , 48 ]. Among them, parameters that showed consistent significant differences in at least four studies included SDNN and RMSSD.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies

2023

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Coronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates the long-term association between COVID-19 and HRV parameters. Four electronic databases were searched up to 29 July 2022. We included observational studies comparing HRV parameters (measurement durations: 1 min or more) in participants with and without a history of COVID-19. We used assessment tools developed by the National Heart, Lung, and Blood Institute group to evaluate the methodological quality of included studies. Eleven cross-sectional studies compared HRV parameters in individuals who recovered from acute COVID-19 infection to controls (n = 2197). Most studies reported standard deviation of normal-to-normal intervals (SDNN) and root mean square of the successive differences. The methodological quality of the included studies was not optimal. The included studies generally found decreased SDNN and parasympathetic activity in post-COVID-19 individuals. Compared to controls, decreases in SDNN were observed in individuals who recovered from COVID-19 or had long COVID. Most of the included studies emphasized parasympathetic inhibition in post-COVID-19 conditions. Due to the methodological limitations of measuring HRV parameters, the findings should be further validated by robust prospective longitudinal studies.

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