Po-675-01 Glucagon-Like Peptide-1 Prevents Atrial Electrical Remodeling in Type 2 Diabetic Db/Db Mice

GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D?

“…Some clinical studies with GLP-1RAs have demonstrated improvement in left ventricular ejection fraction, which is one parameter not affected in the study by Bohne et al. 2 In addition, some GLP-1RAs have been shown to increase heart rate in preclinical studies. 4 In the present study, the authors observed a trend of a mild increase in heart rate with GLP-1RA treatment vs saline treatment.…”

“…In this issue of JACC: Basic to Translational Science , Bohne et al 2 investigated the effect of GLP-1RA treatment in diabetic mice on AF risk. The idea that GLP-1RAs lower AF risk in animal models is not new.…”

“…Bohne et al 2 utilized db/db mice, which are known to have increased AF risk along with structural and electrical abnormalities. They treated these mice for 4 weeks with the GLP-1RA liraglutide by subcutaneous injection or GLP-1 using an implanted pump.…”