PO-62 - Remote ischemic preconditioning in head and neck cancer reconstruction – a randomized controlled trial

Krag, Andreas Engel; Kiil, Birgitte Jul; Hvas, Christine Lodberg; Eschen, Gete Toft; Hvas, Anne‐Mette

doi:10.1016/s0049-3848(16)30195-5

Cited by 1 publication

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“…The benefits include reduced mortality from all causes, weight control, prevention of cancers, increased longevity, improved mental health, and anti-hypertension effects. Chronic RIC has been tested extensively in patients with cerebrovascular diseases, cardiovascular diseases, renal diseases, respiratory diseases and cancer [ 69 , 70 ]. Moreover, chronic RIC has been demonstrated to have sustained blood pressure lowering effect in normotensive or prehypertensive subjects [ 71 , 72 ].…”

Section: Future Investigationsmentioning

confidence: 99%

Chronic Remote Ischemic Conditioning May Mimic Regular Exercise:Perspective from Clinical Studies

Zhao¹,

Li²,

Ren³

et al. 2018

Aging and disease

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Chronic remote ischemic conditioning (RIC), particularly long-term repeated RIC, has been applied in clinical trials with the expectation that it could play its protective roles for protracted periods. In sports medicine, chronic RIC has also been demonstrated to improve exercise performance, akin to improvements seen with regular exercise training. Therefore, chronic RIC may mimic regular exercise, and they may have similar underlying mechanisms. In this study, we explored the common underlying mechanisms of chronic RIC and physical exercise in protecting multiple organs and benefiting various populations, the advantages of chronic RIC, and the challenges for its popularization. Intriguingly, several underlying mechanisms of RIC and exercise have been shown to overlap. These include the production of many autacoids, enhanced ability for antioxidant activity, modulating immune and inflammatory responses. Therefore, it appears that chronic RIC, just like regular exercise, has beneficial effects in unhealthy, sub-healthy and healthy individuals. Compared with regular exercise, chronic RIC has several advantages, which may provide novel insights into the area of exercise and health. Chronic RIC may enrich the modes of exercise, and benefit individuals with severe diseases. Also, the disabled, and sub-healthy individuals are likely to benefit from chronic RIC either as an alternative to exercise or an adjunct to pharmacological or non-pharmacological therapy.

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