PO-411 Novel HIF1α inhibitors suppress cancer cell growth and circumvent multidrug resistance

Abstract

assay using flow cytometry. Data analysis was done using the software CellQuestPro. Results and discussions Our study results demonstrated that the methanol extract of Holothuria scabra exhibited cytotoxic activity through inhibiting the growth of T47D cancer cells in a dose-dependent manner, start from 50 mg/mL until 500 mg/ mL, with IC 50 value of 152.98 mg/mL. The methanol extract of Holothuria scabra was able to stimulate 99% cancer cells to undergo apoptosis. This data warrant for further investigation on that apoptotic mechanism. The investigation is important to support cancer therapeutical strategies that focus on inducing cell death to overcome apoptosis resistance, one of the most important hallmark of cancer. Conclusion The methanol extract of Holothuria scabra contains a promising anti-cancer agent that possesses cytotoxic and apoptotic effects on breast cancer cells.