Abstract:IntroductionNeurofibromin (NF1), a tumour suppressor and RAS-GTPase activating protein, is one of the highly mutated genes in cancer. Dysregulated NF1 expression promotes tumorigenesis, impairs learning and memory and affects neural development. Loss of NF1 expression is observed in approximately 13% of all glioma and is associated with increased malignancy. Additionally, NF1-loss increases glioma stem cells self-renewal, heightens cell invasion, and promotes mesenchymal transition resulting in enhanced tumour… Show more
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