PO-172: Thymoma – Largest Indian Single Institutional Experience

Chowdhary, Rahul Lal; Chufal, Kundan Singh; Pahuja, A.K.; Ahmad, Irfan; Singh, Rita; Sharma, Manoj

doi:10.1016/s0167-8140(20)30514-4

Cited by 1 publication

(2 citation statements)

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“…At a median follow-up of 6 years, our 5-year OS was 67.1% and 5-year DFS was 66.6%. The 5-year OS in our study is considerably lower to that reported by Alothaimeen and Memon (88.6%), 40 Bruni et al (90.2%), 41 Yuan et al (91%), 39 and Chowdhary et al (75.7%), 42 but comparable to Zhu et al (56.5%). 43 Two series from India have reported 3-year OS rates of 83 and 90%.…”

Section: Discussioncontrasting

confidence: 62%

“…However, our local control at 5 years was 86.6% which is higher compared with other series (68-77.8%). 40,[42][43][44] Local control can be considered a surrogate for effectiveness of local treatment. The high local control rates in the present study may be attributed to R0 resection status in more than 90% of our patients and adjuvant RT in all patients, irrespective of stage and histology.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcomes of Thymoma Treated at a Single Institute

Shishak,

Kataria,

Bisht

et al. 2024

South Asian J Cancer

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Introduction Thymomas are uncommon tumors that originate from epithelial cells of thymus and may have varying clinical course. Materials and Methods A retrospective review of medical records of thymoma patients treated between January 2012 and April 2022 at our institute was conducted. Results There were a total of 23 patients (12 males and 11 females) with median age of 52 years (range, 33–77 years). Eleven patients (47.8%) had associated paraneoplastic syndromes of which 10 (43.5%) had myasthenia gravis and 1 (4.3%) had pure red cell aplasia. Average maximal tumor diameter was 62 mm (28–160 mm). Masaoka-Koga stage distribution was as follows: stage I (n = 2, 8.7%), IIA (n = 4, 17.4%), IIB (n = 1, 4.3%), IIIA (n = 2, 8.7%), IIIB (n = 4, 17.4%), IVA (n = 7, 30.4%), and IVB (n = 3, 13.1%). The World Health Organization type B2 was the commonest histology (n = 12, 52.17%), followed by B3 (n =7, 30.4%), B1 (n = 2, 8.7%), AB (n = 1,4.3%), and A (n = 1, 4.3%). Six patients received neoadjuvant chemotherapy with cyclophosphamide regimen, 22 (95.6%) underwent surgery, and 1 patient received adjuvant chemotherapy. R0 resection was attained in 20 (91%) patients, R1 resection in 1 (4.5%) patient, and R2 in 1 (4.5%) patient. All operated patients underwent postoperative radiotherapy (45–60 Gy in 25–30 fractions). Four patients relapsed at a median duration of 14 months (2–26 months). At a median follow-up of 6 years, 5-year overall survival was 67.1% and 5-year progression-free survival was 66.6%. Local control at 5 years was 86.6%. Conclusion Despite majority of our patients presenting at an advanced stage, the local control rates are encouraging and reinforce multimodality approach.

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