PO-0909: Comparison of protective effect of melatonin and amifostine on acute renal damage caused by ionizing radiation

Özen, Alaattin; Tastekin, Ebru; Parlar, Şule; Çakına, Suat; Kurkcu, Nukhet; Uzal, Cem

doi:10.1016/s0167-8140(15)33215-1

Cited by 1 publication

(4 citation statements)

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“…9,18 Various studies have stated that MDA levels increase in tissues exposed to radiation. 10,27 Likewise, in the current study, kidney tissue MDA levels showed an increase after 6 Gy irradiation. Various pieces of research have observed decreases in levels of GSH, a major defender of the organism against oxidative stress occurring in tissues exposed to IR and also an important marker of oxidative stress.…”

Section: Discussionsupporting

confidence: 77%

Section: Vacuolization Of Tubular Epithelial Cellssupporting

confidence: 76%

“…30 min before administration of 6 Gy x-irradiation. 21,26,27 The IR+RG group received 200 mg/kg RG by gavage for 29 days. 22,23,28 On the 29 th day, they were administered one dose of total-body x-irradiation and were sacrificed on day 30.…”

Section: Methodsmentioning

confidence: 99%

“…30 In addition, Özden et al (2013) reported that AM reduces caspase-3 expression in tubular cells caused by a single dose of whole-body 8-Gy irradiation. 27 Cho et al (2019) demonstrated that RG may be beneficial in repairing ionizing radiation-induced colon damage by inhibiting caspase-3 expression. 23 Chang et al (2014) examined the protective effects of RG on radiation-induced oral mucositis through a single dose of 20 Gy IR to the whole body.…”

Section: Groupmentioning

confidence: 99%

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The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation

et al. 2022

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This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues through changes in biochemical and histopathological parameters in addition to contributions to the use of amifostine and RG in clinical studies . Five groups were established: Group I (control, receiving only saline by gavage), Group II (IR only), and Group III (IR+AM, 200 mg/kg intraperitoneally (i.p.). Group IV (IR + RG, 200 mg/kg orally once a day for 4 weeks), and Group V (IR+RG+AM, 200 mg/kg orally once/day for 4 weeks before IR and 200 mg/kg AM administered (i.p.) 30 min before IR). All groups, except for the control group, were subject to 6-Gy whole-body IR in a single fraction. 24 h after irradiation, all animals were sacrificed under anesthesia. IR enhanced MDA, 8-OHdG, and caspase-3 expression while decreasing renal tissue GSH levels ( p < .05). Significant numbers of necrotic tubules together with diffuse vacuolization in proximal and distal tubule epithelial cells were also observed. The examination also revealed substantial brush boundary loss in proximal tubules as well as relatively unusual glomerular structures. While GSH levels significantly increased in the AM, RG, and AM+RG groups, a decrease in KHDS, MDA, 8-OHdG, and caspase-3 expression was observed, compared to the group subject to IR only ( p < .05). Therefore, reactive oxygen species-scavenging antioxidants may represent a promising treatment for avoiding kidney damage in patients receiving radiation.

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