PO-0853 Quality Of Life In Children With Cerebral Palsy And Adhd Before And After Administration Of Treatment

Abstract

timeframes. Similar expression method was applied to hippocampi obtained from children with MTLE and normal controls. Results The expression pattern for the miR-124, miR-134 and miR-9 nearly showed the same dynamics in the three stages of MTLE development to be upregulated in the acute and chronic stages and nearly equal to the control in the latent stage, they upregulated also in the children with MTLE. Conclusions The significant upregualtion for the brain specific miR-124, miR-134 and miR-9 in the seizures related stages and children suggested that both can be a potential targets for anticonvulsant drugs in the epileptic developing brains. Background and aims Prematurity and intrauterine growth restriction (IUGR) is associated with deviations of the developmental trajectory of the brain. We aimed to examine resting state networks (RSNs) in preterm infants with and without IUGR during natural sleep at 12 months. Methods We included 30 preterm infants (<34 weeks) without focal brain lesions (12 with IUGR and 18 appropriate for gestational age) and 20 born-term infants that were scanned at 12 months during natural sleep. Structural and functional MRI was acquired in a 3T scanner. To account for head movement we performed frame censoring of the data. RSNs were computed using the MELODIC module (FSL software). Dual regression analysis was used to query between-group differences in RSNs. PO-0850Results Overall, the degree of movement on functional data was small. In the group we identified nine RSNs encompassing bilaterally the primary visual cortex, auditory cortex, sensori-motor cortex, lateral parietal cortex, precuneus, frontal and a sub-cortical network. Preterm infants had a more prominent cerebellar network compared to term infants. The three groups showed a fragmentized default-mode network. No significant differences were found between groups.Conclusions The spatial patterns of the RSNs observed in preterm and term infants corresponded closely to those observed in adults. These findings may suggest that IUGR and prematurity does not interfere with the normal process of functional brain network development at 12 months of age. The fact that we could not find differences in RSNs does not rule out that alterations could occur later in development. Background and aims Children with cerebral palsy (CP) and their caregivers often report poor quality sleep. A proportion of sleep problems can be linked to physical care needs associated with CP; need for repositioning, pain and hygiene. Simple but effective changes can be made to care regimes that may reduce sleep disturbance. However, sleep issues and the subsequent sleep solutions are frequently overlooked. The aim of this pilot study is to identify why children with CP and their parents/caregivers are awake at night-time. Methods Parents of children with severe CP aged between 6 and 10 years were asked to complete a Time Use Diary (TUD) of their child's night from 6 pm until 9 am for two nights. Results Eight families returned the study documents, yielding a tot...