PO-0814: Initial experiences with coverage probabilitybased nodal SIB RT in cervical cancer

Glavák, Csaba; Toller, Gabor L.; Völgyi, Zoltán; Faour, A.; Bálint, Anita; Miovecz, A.; Kisivan, K.; Romics, Imre; Hadjiev, Janaki; Lakosi, Ferenc

doi:10.1016/s0167-8140(18)31124-1

Cited by 1 publication

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“…The primary lesion and lymphatic drainage area received a total dose of 45–50 Gy in the planned target area. For suspected metastatic lymph nodes based on medical imaging, a synchronous boost or a sequential boost of 5–15 Gy was given 6 . The 30 patients, who were in the supine position, underwent computed tomography (CT) simulated positioning scanning; the CT images were transmitted to the Pinnacle 9.10 treatment planning system.…”

Section: Methodsmentioning

confidence: 99%

“…For suspected metastatic lymph nodes based on was given. 6 The 30 patients, who were in the supine position, underwent computed tomography (CT) simulated positioning scanning; the CT images were transmitted to the Pinnacle 9.10 treatment planning system. The planned target area included the vaginal stump, vaginal part, and lymph node drainage area.…”

Section: External Radiation Therapymentioning

confidence: 99%

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An exploratory study of the dose correlation between point B and metastatic lymph nodes in three‐dimensional high‐dose‐rate brachytherapy for cervical cancer

Yang

Gao

2022

Precision Radiation Oncology

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Objective: To determine the dose correlation between point B and metastatic lymph nodes in cervical cancer treated with three-dimensional (3D) high-dose-rate (HDR) brachytherapy.Methods: A retrospective study was conducted involving 30 cervical cancer patients with lymph node metastases who completed 3D HDR brachytherapy at Liaoning Cancer Hospital and Institute from May 2019 to November 2020. Brachytherapy was performed with a Fletcher applicator at a prescribed dose of 28 Gy/4 f. Computed tomography images of the external irradiation target were fused with delineated images of the brachytherapy target on the MIM system. The minimum dose received by 90% of the volume (D 90 ) was read on the MIM system for all metastatic lymph nodes and the point B dose was read for the brachytherapy target area. In total, 78 metastatic lymph nodes from 30 patients with cervical cancer were included in this study, including para-aortic, common iliac, external iliac, internal iliac, obturator, and inguinal lymph nodes. Paired t-tests and Pearson correlation coefficient analyses were performed to examine the difference in the equivalent dose between each group of metastatic lymph nodes and point B. Results:The mean equivalent point B dose was 6.69 ± 1.08 Gy. There were significant differences in dose between point B and the para-aortic, common iliac, external iliac, internal iliac, and inguinal lymph nodes (p < 0.05), with a weak positive correlation (r < 0.4). There was no statistically significant difference in dose between obturator lymph nodes and point B (p = 0.3999), with a positive correlation (r = 0.65). Conclusion:3D HDR brachytherapy contributed significantly to pelvic lymph node doses in cervical cancer patients with lymph node metastasis, but less to para-aortic and inguinal lymph node doses. The dose at point B grossly overestimated the mean dose to pelvic lymph nodes; only the dose to obturator lymph nodes was similar to that of point B, with a slightly positive correlation.

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Section: Methodsmentioning

confidence: 99%

Section: External Radiation Therapymentioning

confidence: 99%