PO-0713 PDRN-based cream in the prevention and treatment of radiodermatitis in Head and nech cancer: our experience.

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

“…Insufficient evidence was reported to support the use of urea, Xonrid, hydroactive colloid gel, and other interventions. 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 Topical corticosteroids 18 (15) 1715 (81; 12–219) Mometasone furoate (8); Betamethasone (6); Other (4) Breast (14); Head and neck (3); Multiple (1) Mometasone furoate and betamethasone were both generally found to be effective in ARD prevention. There is insufficient evidence supporting the use of other corticosteroids, such as hydrocortisone and beclomethasone.…”

“…A total of 42 studies assessed topical non-steroidal agents for the prevention of ARD, including 12 and 28 non-randomized studies and RCTs, respectively 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ( Appendix C, Table 1 ). The majority of RCTs assessed trolamine-based products (including Biafine ®), 14 , 15 , 16 , 17 , 18 , 21 , 33 hyaluronic acid/hyaluronan-based products, 22 , 23 , 24 , 25 , 26 and heparinoid (Hirudoid ®).…”

“…The majority of RCTs assessed trolamine-based products (including Biafine ®), 14 , 15 , 16 , 17 , 18 , 21 , 33 hyaluronic acid/hyaluronan-based products, 22 , 23 , 24 , 25 , 26 and heparinoid (Hirudoid ®). 30 , 31 , 197 A few RCTs demonstrated promising results in the use of trolamine emulsion, 14 , 21 hyaluronic acid/hyaluronan, 22 , 24 , 25 3M™ Cavilon™ Durable Barrier Cream, 34 , 35 heparinoid (Hirudoid), 30 , 31 boron-based gel, 37 and other emulsions 38 , 47 , 50 , 52 ; however, evidence supporting the use of these interventions was either conflicting or insufficient to produce recommendations for clinical practice.…”