PO-0364 Histological Aspects Of The Feto-placental Interface In The Pregnancy Induced Hypertension

Ilie, Rodica; Ilie, Constantin; Capitan, Florina; Nyiredi, Alexandra; Enatescu, I.

doi:10.1136/archdischild-2014-307384.1012

Cited by 2 publications

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“…Consequently, uteroplacental perfusion reduces, and the placenta becomes ischemic as gestation progresses [ 17 , 18 ]. This causes fetal hypoxia as well as morphological and histological changes in the placenta, leading to PE or PE-associated IUGR, which contributes to premature delivery and fetal death [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Histomorphological and morphometrical changes of placental terminal villi of normotensive and preeclamptic mothers

et al. 2013

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Placental morphology and cellular arrangement are altered in maternal diseases such as preeclampsia (PE) in which oxygen delivery from the mother to the fetus is greatly disturbed, ultimately resulting in cellular oxidative stress. The present study was conducted at the Department of Anatomy and included 112 placentas (56 each from mothers with and without PE [controls]) collected at the Department of Obstetrics and Gynecology. A histological study was performed using hematoxylin and eosin staining. The morphology of stem and terminal villi (TV) was studied, and the surface area and diameter of TV and capillaries were measured. The gross placental morphometrical study revealed that the mean placental weight, thickness, diameter, and surface area were significantly lower in placentas with PE than in controls. The histomorphometrical findings of the villous surface area and diameter were lower in placentas with PE, whereas the TV density was higher in placentas with PE than in controls, and the differences were significant (P<0.0001). In these TV, the diameter and density of fetal blood vessels of placentas with PE were significantly lower than those of controls (P<0.05). In conclusion, the both morphological and histological changes in PE placentas are indicative of the pathogenesis of maternal and fetal morbidity and mortality in women with PE. The observed and comparative histomorphometrical changes indicate a decline in all aspects of the PE placenta, except the number of TV.

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Section: Introductionmentioning

confidence: 99%

Histomorphological and morphometrical changes of placental terminal villi of normotensive and preeclamptic mothers

et al. 2013

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“…10,26 A better understanding of these abnormalities can change our medical assistance during the pregnancy in future. 20 Thus more precise intervention strategies should be devised that can contribute to effective management of the condition which will help to bring down the fetal and maternal mortality and morbidity. 17…”

Section: Discussionmentioning

confidence: 99%

“…5,[17][18][19] Fibrinoid necrosis and hyalinization leads to placental insufficiency and ultimately to foetal growth retardation. 5,17,18,20 Cytotrophoblastic cellular proliferation, syncytial knot formation and fibrin plaque formation in greater amount is seen in preeclamptic placenta. 17,18…”

Section: Alterations Of Placenta In Preeclampsiamentioning

confidence: 99%

Morphological and histological variations of human placenta in pregnancies affected with preeclampsia and gestational diabetes – A review

Vinod

Pushpalatha²,

S³

2022

IJOGR

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The placenta is a transitory organ that is situated between the mother and the foetus. This vital organ which has nutritional, endocrine and immunologic functions so as to maintain pregnancy and promote fetal development. Several factors are related to the proper functioning of the placenta including foetal and maternal blood flow, appropriate nutrients, expression and function of receptors and transporters, and also the morphology of the placenta itself. Gestational hypertension and gestational diabetes are among the most frequent obstetric disorders during pregnancy. Pregnancies complicated with one or both of these disorders are also associated with adverse consequences for the mother and infant (both acute and long-term). Preeclampsia being one of the toxemias of pregnancy is a condition of increased blood pressure accompanied by proteinuria, edema or both. Various changes like increased syncytial knots, cytotrophoblastic cell proliferation, villous stromal fibrosis and fibrinoid necrosis was observed in placenta from preeclamptic cases. Diabetes mellitus can be defined as a chronic disorder marked by high blood glucose levels and a disruption in fat and protein metabolism. In pregnancies affected by diabetes mellitus also several changes occur like placental size, increased glycogen deposits, increased volume of intervillous space and terminal villi, fibrinoid areas, and glycogen deposits compared to others.All these changes may result in functional changes in this organ thus limiting the wellbeing of the developing foetus. Therefore, this review as a whole gives an overview of morphological changes at macroscopic and histological levels seen in the placenta from gestational diabetes and preeclampsia.

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PO-0364 Histological Aspects Of The Feto-placental Interface In The Pregnancy Induced Hypertension

Cited by 2 publications

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Histomorphological and morphometrical changes of placental terminal villi of normotensive and preeclamptic mothers

Histomorphological and morphometrical changes of placental terminal villi of normotensive and preeclamptic mothers

Morphological and histological variations of human placenta in pregnancies affected with preeclampsia and gestational diabetes – A review

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