PO-0191 Varicella Complications - Could We Do More?

Komitova, Р.; Boev, Igor; Kazakova, Z; Bojilova, M; Bojkinova, O

doi:10.1136/archdischild-2014-307384.850

Cited by 3 publications

(6 citation statements)

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“…cerebellitis, encephalitis, status epilepticus). Notably, the overwhelming majority of patients who developed complications were immunocompetent and previously healthy [25,30]. Neither of the two studies with evidence on mortality in the CEE region reported any varicella-related deaths [23,28].…”

Section: Complications/mortalitymentioning

confidence: 95%

“…Varicella-associated complications were explored in seven studies originating from CEE countries, including Albania, Poland, Bosnia-Herzegovina, Bulgaria, and Romania, in addition to two national reports from Slovenia and Lithuania [17,22,25,26,[30][31][32]40,41]. The majority of the studies did not describe the vaccination status of patients; studies that did so were conducted on unvaccinated groups [25,31].…”

Section: Complications/mortalitymentioning

confidence: 99%

“…Nine studies provided evidence on resource use and hospitalization rates in Slovenia [20,28,29], Poland [25,27,31], Bulgaria [30], and Albania [26]. The EUVAC surveillance study, mentioned above, described wide variations in hospitalization rates across CEE.…”

Section: Resource Use and Hospitalization Ratesmentioning

confidence: 99%

“…In data available from Poland, Albania, and Bulgaria, the mean length of hospital stay ranged from 5 to 7 days [25,26,30,31]. Hospitalization rates in a Polish population over the period 2007-2011 generally remained constant, ranging from 0.51% to 0.59% [25,27].…”

Section: Resource Use and Hospitalization Ratesmentioning

confidence: 99%

See 3 more Smart Citations

Burden of varicella in Central and Eastern Europe: findings from a systematic literature review

Mészner

Wysocki

Richter

et al. 2019

Expert Review of Vaccines

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Introduction: Vaccination against varicella rapidly reduces disease incidence, resulting in reductions in both individual burden and societal costs. Despite these benefits, there is no standardization of varicella immunization policies in Europe, including countries in Central and Eastern Europe (CEE). Areas covered: This systematic literature review identified publications on the epidemiology of varicella, its associated health and economic burden, and vaccination strategies within the CEE region, defined as Albania,

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Section: Complications/mortalitymentioning

confidence: 95%

Section: Complications/mortalitymentioning

confidence: 99%

Section: Resource Use and Hospitalization Ratesmentioning

confidence: 99%

Section: Resource Use and Hospitalization Ratesmentioning

confidence: 99%

See 2 more Smart Citations

Burden of varicella in Central and Eastern Europe: findings from a systematic literature review

Mészner

Wysocki

Richter

et al. 2019

Expert Review of Vaccines

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“…According to data of the Ministry of Health for the last three years -2017, 2018, 2019 -the cases were respectively 24,970, 23,402 and 30,183 within a population of 6,951,482 in December 2019 [5,6]. More than 10% of the adult population in Bulgaria is seronegative, which shows a high sensitivity of the more vulnerable part of the population and is a precondition for more frequent complications and subsequent hospitalizations [4,7].…”

Section: Introductionmentioning

confidence: 99%

Complications of Chickenpox in Bulgaria – Data from a Single-Center Experience

Popov

Antonov

Velev

et al. 2021

Acta Medica Bulgarica

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Primary Varicella zoster infection (chickenpox) in childhood is a common benign disease. The predominance of uncomplicated cases in children often overshadows the rarer cases of complicated severe course of the disease. Objective To study the complications of primary chickenpox in hospitalized patients for a period of one year. Materials and Methods 122 patients with complicated primary chickenpox with an average age of 18.6 years; 57 males (46.7%) and 64 females (53.3%), were hospitalized at the University Hospital of Infectious and Parasitic Diseases “Prof. Iv. Kirov” in the period January – December 2019. Results The bacterial infections of the skin and soft tissues comprised the largest relative frequenchy – they occurred in 74 (60.6%) of the patients; followed by pneumonia – in 31 (25.4%) patients, and a combination of pneumonia and pustulation – in 10 (8.2%) patients. Cerebelitis was observed in 1 (0.8%) patient. One of the patients developed hepatitis, purulent arthritis and acute enteritis. We also report the death of one patient. Conclusions We registered a relatively high proportion of hospitalizations, especially in young children and adults. Regarding the type of complications, we do not describe significant differences compared to other authors. Although in most cases primary chickenpox is a self-limiting disease, complications are more common in the countries where there is no vaccine.

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Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis

Shah,

Meiwald,

Perera

et al. 2023

Infect Dis Ther

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Introduction Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and adults. Varicella symptoms are usually self-limiting; however, different complications with widespread and systemic manifestations can occur. This systematic literature review aims to explore and quantify varicella-associated complication rates. Methods Two databases (Embase and MEDLINE), congress abstracts, and reference lists of systematic reviews were screened to identify evidence on varicella complications. Complications were identified and grouped into 14 clinically relevant categories. Proportional meta-analyses were conducted using a random-effects model and tests for heterogeneity and publication bias were performed. Subgroup, sensitivity, and meta-regression analyses were also conducted. A total of 78 studies, spanning 30 countries, were included in the meta-analysis. Results Pooled prevalence was highest in severe varicella (22.42%; 95% confidence interval [CI] 10.13–37.77), skin-related complications (20.12%; 95% CI 15.48–25.20), and infection-related complications (10.03%; 95% CI 7.47–12.90). Cardiovascular (0.55%; 95% CI 0.08–1.33), genitourinary (1.17%; 95% CI 0.55–1.99), and musculoskeletal (1.54%; 95% CI 1.06–2.11) complications had the lowest pooled prevalence. The remaining complication categories ranged between 1% and 10%. Subgroup analysis showed that complications were more prevalent in children versus adults and in hospitalized patients versus outpatients. Meta-regression analysis found that no ecological level covariates were accurate predictors for the overall prevalence of varicella-associated complications. There was substantial heterogeneity and publication bias across all meta-analyses. Conclusion Results suggest that different types of varicella-associated complications could be frequent, impacting quality of life, and healthcare resource utilisation and budgets. These findings are crucial to raise awareness of the health and economic burden of varicella disease. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00899-7.

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PO-0191 Varicella Complications - Could We Do More?

Cited by 3 publications

References 0 publications

Burden of varicella in Central and Eastern Europe: findings from a systematic literature review

Burden of varicella in Central and Eastern Europe: findings from a systematic literature review

Complications of Chickenpox in Bulgaria – Data from a Single-Center Experience

Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis

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