PO-0140 Whether Antimicrobial Therapy Affect Fecal Excretion Time In Paediatric Patients Of Nontyphoid Salmonellosis With Different Severity

Abstract

0.001) and coagulopathy/ thrombocytopenia, PRISM III ≥ 10, renal and hepatic failure, hypotension, and heart failure/ arrhythmia was found to be associated with the development of GIB in critically ill children (p < 0.05). Conclusions GIB is a serious concern for PICU clinicians and intensivists are confused about the conflicting evidence supporting prophilaxis. We believe that prophylaxis could be beneficial for mechanically ventilated children. Also trauma, coagulopathy/ thrombocytopenia, PRISM III ≥ 10, renal and hepatic failure, hypotension, and heart failure/arrhythmia must be kept in mind as risk factors requiring attention in PICU setting.

Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review

“…Inappropriate use of antibiotics, however, does seem to significantly prolong the time of excretion, as shown in patients with mild disease receiving antibiotics or patients with severe disease receiving antibiotics later being found to be resistant in vitro [47,60]. So, in accordance to published guidelines and generally accepted assumption, these results confirm that, especially for mild clinical courses of NTS diarrhea, empiric antibiotic treatment should generally be avoided [33,38,52].…”

“…According to our literature review, adequate antibiotic treatment in vulnerable groups or children already presenting considerably ill with substantially elevated CRP-levels or fever seems to outweigh the questionable risk of a prolongation of fecal NTS excretion. Targeted antibiotic therapy should be performed whenever possible according to antimicrobial activity in vitro susceptibility testing [47,60].…”