PNS36 Cost-Benefit Analysis of Dental Prevention Programs for Children in Taiwan

Abstract

Objectives: Regulatory science (RS) grounds its value on enhancing regulatory capacity through developing and adopting scientific disciplines applicable to the evaluation of health-related products. While drug regulatory authorities (DRAs) are increasingly engaged with RS, their approaches have not been systemically examined. This research aimed to analyze the experiences of RS development based on a cross-country comparison guided by the logic modeling. Methods: DRAs in China (National Medical Products Administration, NMPA), the United States (Food and Drug Administration, FDA), the European Union (European Medicines Agency, EMA) and Japan (Pharmaceuticals and Medical Devices Agency, PMDA) were the study targets as they had officially launched RA initiatives. Documentary analysis of government documents and scoping literature review were conducted for data collection.

Cost-Effectiveness of Pit and Fissure Sealing at Schools for Caries Prevention in China: A Markov Modeling Analysis

“…The results of this study showed that compared with the control group, the benefits of applying PFS from both perspectives were greater than the costs (BCR >1), and the BCR was higher from the societal perspective. It is consistent with the findings in Taiwan that the application of PFS is more cost-effective compared to not sealing [Lai et al, 2020]. PFS has a protective effect on the teeth and prevents 16.06 million dental caries lesions in the PFMs.…”

“…Studies generated Markov models [Quiñonez et al, 2005;Bertrand et al, 2011;Espinoza-Espinoza et al, 2019] and decision tree models [Halasa-Rappel et al, 2021] to focus on the costs and effects of PFS application on children's permanent molars. Cost-effectiveness analysis is mostly used, and fewer studies have conducted cost-benefit analysis [Lai et al, 2020] and cost-utility analysis [Bhuridej et al, 2007;Espinoza-Espinoza et al, 2019]. Although short-term analyses of the economics of PFS application have been conducted in some parts of China [Lai et al, 2020;Yang and Li, 2016], there is still a lack of high-quality evidence from China at the national level.…”

“…Cost-effectiveness analysis is mostly used, and fewer studies have conducted cost-benefit analysis [Lai et al, 2020] and cost-utility analysis [Bhuridej et al, 2007;Espinoza-Espinoza et al, 2019]. Although short-term analyses of the economics of PFS application have been conducted in some parts of China [Lai et al, 2020;Yang and Li, 2016], there is still a lack of high-quality evidence from China at the national level. Therefore, this study aimed to develop a multi-perspective, multistate Markov model to estimate the cost and effect of PFS application in schools in China to prevent dental caries.…”